Cloned (Comment) | Organism |
---|---|
expression of wild-type enzyme and mutant S586A in HEK293 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
S586A | naturally occuring mutation leading to phosphorylation of VLCAD at Ser586 is inhibited in myofibroblasts, resulting in a significant loss of enzyme activity coupled with lipid peroxidation. The S586A mutant shows a significant reduction in electron transfer activity | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | phosphorylation of Ser586 is essential for VLCAD function | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
LF2 cell | - |
Homo sapiens | - |
myofibroblast | - |
Homo sapiens | - |
TIG-7 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
very long chain acyl-CoA dehydrogenase | - |
Homo sapiens |
VLCAD | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | phosphorylation of VLCAD at Ser586 is inhibited in myofibroblasts, resulting in a significant loss of enzyme activity coupled with lipid peroxidation.Thus Ser586 represents a critical site for VLCAD activity, whose dysregulation might contribute to the progression of idiopathic pulmonary fibrosis, IPF, a chronic interstitial lung disease, and other oxidative-stress mediated diseases | Homo sapiens |
physiological function | VLCAD is a rate-limiting enzyme in fatty acid beta-oxidation and is regulated by phosphorylation at Ser586 | Homo sapiens |