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Literature summary for 1.3.8.8 extracted from

  • Okamura-Ikeda, K.; Ikeda, Y.; Tanaka, K.
    An essential cysteine residue located in the vicinity of the FAD-binding site in short-chain, medium-chain, and long-chain acyl-CoA dehydrogenases from rat liver mitochondria (1985), J. Biol. Chem., 260, 1338-1345.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
AgNO3 strong inhibition of apo and holo forms at 0.1 mM Rattus norvegicus
CuCl2 strong inhibition of apo and holo forms at 0.1 mM Rattus norvegicus
HgCl2 strong inhibition of apo and holo forms at 0.1 mM Rattus norvegicus
iodoacetic acid 50% inhibition of apoenzyme at 2 mM, not inhibitory for the holo form Rattus norvegicus
Methylmercury chloride strong inhibition of apo and holo forms at 1 mM Rattus norvegicus
Methylmercury iodide strong inhibition of the apoenzyme at 0.1 mM, not inhibitory for the holo form Rattus norvegicus
N-ethylmaleimide strong inhibition of the apoenzyme at 2 mM, not inhibitory for the holo form even at higher concentrations like 5 mM Rattus norvegicus
p-hydroxymercuribenzoate strong inhibition of the apoenzyme at 0.1 mM, not inhibitory for the holo form even at higher concentrations like 1 mM Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Rattus norvegicus 5739
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.48
-
purified apoenzyme, palmitoyl-CoA Rattus norvegicus
1.5
-
purified holoenzyme, palmitoyl-CoA Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
palmitoyl-CoA + phenazine methosulfate
-
Rattus norvegicus 2-hexadecenoyl-CoA + reduced phenazine methosulfate
-
?

Cofactor

Cofactor Comment Organism Structure
FAD
-
Rattus norvegicus