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Literature summary for 1.3.5.2 extracted from

  • Stocks, P.A.; Barton, V.; Antoine, T.; Biagini, G.A.; Ward, S.A.; ONeill, P.M.
    Novel inhibitors of the Plasmodium falciparum electron transport chain (2014), Parasitology, 141, 50-65.
    View publication on PubMed
Search for more literature for 1.3.5.2

Inhibitors

Inhibitors Comment Organism Structure
(2E)-2-cyano-N-(2',3-dichloro[1,1'-biphenyl]-4-yl)-3-hydroxybut-2-enamide
-
 Plasmodium falciparum
(2E)-N-(3-chloro-2'-methoxy[1,1'-biphenyl]-4-yl)-2-cyano-3-hydroxybut-2-enamide
-
 Plasmodium falciparum
(2E)-N-[2'-chloro-3-(trifluoromethyl)[1,1'-biphenyl]-4-yl]-2-cyano-3-hydroxybut-2-enamide
-
 Plasmodium falciparum
2,8-dimethyl-N-[4-(trifluoromethyl)phenyl]pyrrolo[1,2-a]pyrimidin-4-amine
-
 Plasmodium falciparum
2-[[(4-chlorophenyl)methyl]sulfanyl]-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one
-
 Plasmodium falciparum
5-(4-cyano-2-methyl-1H-benzimidazol-1-yl)-N-cyclopropylthiophene-2-carboxamide
-
 Plasmodium falciparum
7-methyl-N-(naphthalen-2-yl)imidazo[1,2-a]pyrimidin-5-amine
-
 Plasmodium falciparum
7-methyl-N-(naphthalen-2-yl)[1,2,4]triazolo[1,5-a]pyridin-5-amine
-
 Plasmodium falciparum
A77-1726 potent inhibitor Plasmodium falciparum
brequinar poor inhibitor Plasmodium falciparum
leflunomide poor inhibitor Plasmodium falciparum
N-cyclopropyl-5-[4-(difluoromethoxy)-2-methyl-1H-benzimidazol-1-yl]thiophene-2-carboxamide
-
 Plasmodium falciparum

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Plasmodium falciparum 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-dihydroorotate + coenzyme Q Plasmodium falciparum
-
 orotate + reduced coenzyme Q
-
 ?

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-dihydroorotate + coenzyme Q
-
 Plasmodium falciparum orotate + reduced coenzyme Q
-
 ?

Synonyms

Synonyms Comment Organism
DHOD
-
 Plasmodium falciparum
DHODase
-
 Plasmodium falciparum

Cofactor

Cofactor Comment Organism Structure
FMN dependent on Plasmodium falciparum

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000077
-
 pH and temperature not specified in the publication Plasmodium falciparum 2,8-dimethyl-N-[4-(trifluoromethyl)phenyl]pyrrolo[1,2-a]pyrimidin-4-amine
0.001
-
 pH and temperature not specified in the publication Plasmodium falciparum 2-[[(4-chlorophenyl)methyl]sulfanyl]-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one