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Literature summary for 1.3.5.2 extracted from

  • Patel, V.; Booker, M.; Kramer, M.; Ross, L.; Celatka, C.; Kennedy, L.; Dvorin, J.; Duraisingh, M.; Sliz, P.; Wirth, D.; Clardy, J.
    Identification and characterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase (2008), J. Biol. Chem., 283, 35078-35085.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
4-pentyl-1,3,4,10-tetrahydroacridin-9(2H)-one
-
Plasmodium berghei
4-pentyl-1,3,4,10-tetrahydroacridin-9(2H)-one
-
Plasmodium falciparum
4-pentyl-1,3,4,10-tetrahydroacridin-9(2H)-one
-
Plasmodium vivax
5-(2-methyl-1H-indol-1-yl)-N-propylthiophene-2-carboxamide
-
Plasmodium berghei
5-(2-methyl-1H-indol-1-yl)-N-propylthiophene-2-carboxamide
-
Plasmodium falciparum
5-(2-methyl-1H-indol-1-yl)-N-propylthiophene-2-carboxamide
-
Plasmodium vivax
ethyl 4-(4-ethoxybenzyl)-3,5-dimethyl-1H-pyrrole-2-carboxylate
-
Plasmodium berghei
ethyl 4-(4-ethoxybenzyl)-3,5-dimethyl-1H-pyrrole-2-carboxylate
-
Plasmodium falciparum
ethyl 4-(4-ethoxybenzyl)-3,5-dimethyl-1H-pyrrole-2-carboxylate
-
Plasmodium vivax
N-cyclopropyl-5-(2,3-dihydro-4H-1,4-benzothiazin-4-yl)thiophene-2-carboxamide
-
Plasmodium berghei
N-cyclopropyl-5-(2,3-dihydro-4H-1,4-benzothiazin-4-yl)thiophene-2-carboxamide
-
Plasmodium falciparum
N-cyclopropyl-5-(2,3-dihydro-4H-1,4-benzothiazin-4-yl)thiophene-2-carboxamide
-
Plasmodium vivax

Organism

Organism UniProt Comment Textmining
Plasmodium berghei
-
-
-
Plasmodium falciparum Q08210
-
-
Plasmodium vivax
-
-
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00004
-
pH 8.0 Plasmodium vivax ethyl 4-(4-ethoxybenzyl)-3,5-dimethyl-1H-pyrrole-2-carboxylate
0.000042
-
pH 8.0 Plasmodium falciparum 5-(2-methyl-1H-indol-1-yl)-N-propylthiophene-2-carboxamide
0.00006
-
pH 8.0 Plasmodium berghei 5-(2-methyl-1H-indol-1-yl)-N-propylthiophene-2-carboxamide
0.00006
-
pH 8.0 Plasmodium berghei ethyl 4-(4-ethoxybenzyl)-3,5-dimethyl-1H-pyrrole-2-carboxylate
0.000083
-
pH 8.0 Plasmodium falciparum ethyl 4-(4-ethoxybenzyl)-3,5-dimethyl-1H-pyrrole-2-carboxylate
0.00011
-
pH 8.0 Plasmodium berghei 4-pentyl-1,3,4,10-tetrahydroacridin-9(2H)-one
0.00025
-
pH 8.0 Plasmodium falciparum N-cyclopropyl-5-(2,3-dihydro-4H-1,4-benzothiazin-4-yl)thiophene-2-carboxamide
0.00028
-
pH 8.0 Plasmodium vivax N-cyclopropyl-5-(2,3-dihydro-4H-1,4-benzothiazin-4-yl)thiophene-2-carboxamide
0.00034
-
pH 8.0 Plasmodium falciparum 4-pentyl-1,3,4,10-tetrahydroacridin-9(2H)-one
0.00038
-
pH 8.0 Plasmodium berghei N-cyclopropyl-5-(2,3-dihydro-4H-1,4-benzothiazin-4-yl)thiophene-2-carboxamide
0.00042
-
pH 8.0 Plasmodium vivax 5-(2-methyl-1H-indol-1-yl)-N-propylthiophene-2-carboxamide
0.00051
-
pH 8.0 Plasmodium vivax 4-pentyl-1,3,4,10-tetrahydroacridin-9(2H)-one