Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
in complex with inhibitors 6-chloro-2-(2'-fluorobiphenyl-4-yl)quinoline-4-carboxylic acid and and without any bound inhibitor, to 2.3 A, 2.1 A, and 3.0 A resolution, respectively. Inhibitor 5-methoxy-2-[(4-phenoxyphenyl)amino]benzoic acid 5-methoxy-2-[(4-phenoxyphenyl)amino]benzoic acid interacts with residue Y356. Loop region of residues L68-R72 may interfere with inhibitor/cofactor binding. Loop region N212-L224 may be important for the enzymatic reaction | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-methoxy-2-[(4-phenoxyphenyl)amino]benzoic acid | - |
Homo sapiens | |
6-chloro-2-(2'-fluorobiphenyl-4-yl)quinoline-4-carboxylic acid | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q02127 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-dihydroorotate + 2,6-dichlorophenolindophenol | - |
Homo sapiens | orotate + reduced 2,6-dichlorophenolindophenol | - |
? |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000015 | - |
pH 8.0, 22°C | Homo sapiens | 6-chloro-2-(2'-fluorobiphenyl-4-yl)quinoline-4-carboxylic acid | |
0.000081 | - |
pH 8.0, 22°C | Homo sapiens | 5-methoxy-2-[(4-phenoxyphenyl)amino]benzoic acid |