Literature summary for 1.3.5.2 extracted from

Knecht, W.; Henseling, J.; Loffler, M.
Kinetics of inhibition of human and rat dihydroorotate dehydrogenase by atovaquone, lawsone derivatives, brequinar sodium and polyporic acid (2000), Chem. Biol. Interact., 124, 61-76.

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Inhibitors

Inhibitors	Comment	Organism	Structure
atovaquone	competitive to quinone	Homo sapiens
atovaquone	competitive to quinone	Rattus norvegicus
dichloroallyl-lawsone	competitive to quinone	Homo sapiens
dichloroallyl-lawsone	competitive to quinone	Rattus norvegicus
Lapachol	-	Homo sapiens
Lapachol	-	Rattus norvegicus
Lawsone	-	Homo sapiens
Lawsone	-	Rattus norvegicus
additional information	kinetics of inhibition	Homo sapiens
additional information	kinetics of inhibition	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	recombinant protein	-
Rattus norvegicus	-	recombinant protein	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
dihydroorotate + acceptor	acceptor (low activity): 1,4-naphthoquinone, 5,8-hydroxy-naphthoquinone, juglon, plumbagin, polyporic acid	Homo sapiens	orotate + reduced acceptor	-	?
dihydroorotate + acceptor	acceptor (low activity): 1,4-naphthoquinone, 5,8-hydroxy-naphthoquinone, juglon, plumbagin, polyporic acid	Rattus norvegicus	orotate + reduced acceptor	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.00001	-	dichloro-allyllawsone	-	Rattus norvegicus
0.000061	-	Lapachol	-	Rattus norvegicus
0.000067	-	dichloro-allyllawsone	-	Homo sapiens
0.000618	-	Lapachol	-	Homo sapiens
0.000698	-	atovaquone	-	Rattus norvegicus
0.015	-	atovaquone	-	Homo sapiens
0.049	-	Lawsone	-	Rattus norvegicus
0.5	-	Lawsone	-	Homo sapiens

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Release 2023.1 (January 2023)