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Literature summary for 1.3.5.2 extracted from
- Dihydroorotate dehydrogenase (Escherichia coli) (1978), Methods Enzymol., 51, 58-63.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| deoxycholate | - |
Escherichia coli |  |
| Dodecyl sulfate | - |
Escherichia coli | |
| fatty acids | - |
Escherichia coli | |
| Orotate | - |
Escherichia coli | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.01 | - |
dihydroorotate | - |
Escherichia coli | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 67000 | - |
gel filtration | Escherichia coli |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dihydroorotate + acceptor | Escherichia coli | physiological electron acceptor: ubiquinone (aerobic conditions), menaquinone (anaerobic conditions) | orotate + reduced acceptor | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Escherichia coli |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 3.63 | - |
- |
Escherichia coli |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -18°C, stable | Escherichia coli |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dihydroorotate + acceptor | acceptor: 2,6-dichlorophenolindophenol | Escherichia coli | orotate + reduced acceptor | - |
? | |
| dihydroorotate + acceptor | acceptor: menaquinone | Escherichia coli | orotate + reduced acceptor | - |
? | |
| dihydroorotate + acceptor | acceptor: ubiquinone | Escherichia coli | orotate + reduced acceptor | - |
? | |
| dihydroorotate + acceptor | physiological electron acceptor: ubiquinone (aerobic conditions), menaquinone (anaerobic conditions) | Escherichia coli | orotate + reduced acceptor | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| flavin | enzyme contains flavin | Escherichia coli | |
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