Literature summary for 1.3.5.1 extracted from

Xiao, W.; Sarsour, E.H.; Wagner, B.A.; Doskey, C.M.; Buettner, G.R.; Domann, F.E.; Goswami, P.C.
Succinate dehydrogenase activity regulates PCB3-quinone-induced metabolic oxidative stress and toxicity in HaCaT human keratinocytes (2016), Arch. Toxicol., 90, 319-332 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HaCaT cell	-	Homo sapiens	-

Expression

Organism	Comment	Expression
Homo sapiens	1-(4-chlorophenyl)-benzo-2,5-quinone treatment decreases in the mRNA levels of succinate dehydrogenase (complex II) subunits C and D (sdhc and sdhd). The decrease in sdhc and sdhd expression is associated with a significant decrease in complex II activity and increase in mitochondrial levels of reactive oxygen species	down

General Information

General Information	Comment	Organism
physiological function	overexpression of SdhC and SdhD suppresses 1-(4-chlorophenyl)-benzo-2,5-quinone-induced inhibition of complex II activity, increase in mitochondrial levels of reactive oxygen species, and toxicity	Homo sapiens

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Release 2023.1 (January 2023)