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Literature summary for 1.3.5.1 extracted from

  • Oyedotun, K.S.; Lemire, B.D.
    The Quinone-binding sites of the Saccharomyces cerevisiae succinate-ubiquinone oxidoreductase (2001), J. Biol. Chem., 276, 16936-16943.
    View publication on PubMed
Search for more literature for 1.3.5.1

Protein Variants

Protein Variants Comment Organism
F69V mutation in anchor subunit Sdh4, 56% of wild-type kcat Saccharomyces cerevisiae
H99L mutation in anchor subunit Sdh4, 29% of wild-type kcat Saccharomyces cerevisiae
S71A mutation in anchor subunit Sdh4, 43% of wild-type kcat Saccharomyces cerevisiae
Y89OCH substitution with stop codon truncates Sdh4 by removing the third predicted transmembrane segment, 22% of wild-type activity Saccharomyces cerevisiae

Inhibitors

Inhibitors Comment Organism Structure
2-sec-butyl-4,6-dinitrophenol non-competitive inhibition Saccharomyces cerevisiae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0037
-
 2,3-Dimethoxy-5-methyl-6-decyl-1,4-benzoquinone 22°C Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Saccharomyces cerevisiae 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
succinate + ubiquinone Saccharomyces cerevisiae
-
 fumarate + ubiquinol
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
succinate + 2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone
-
 Saccharomyces cerevisiae fumarate + 2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinol
-
 ?
succinate + ubiquinone
-
 Saccharomyces cerevisiae fumarate + ubiquinol
-
 ?

Synonyms

Synonyms Comment Organism
complex II
-
 Saccharomyces cerevisiae
SDH
-
 Saccharomyces cerevisiae

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
40
-
 no loss of activity after 10 min Saccharomyces cerevisiae
65
-
 almost complete loss of activity after 10 min Saccharomyces cerevisiae
68
-
 approx. 50% loss of activity after 10 min Saccharomyces cerevisiae

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.6
-
 2,3-Dimethoxy-5-methyl-6-decyl-1,4-benzoquinone 22°C Saccharomyces cerevisiae