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Literature summary for 1.3.5.1 extracted from

  • Saruta, F.; Kuramochi, T.; Nakamura, K.; Takamiya, S.; Yu, Y.; Aoki, T.; Sekimizu, K.; Kojima, S.; Kita, K.
    Stage-specific isoforms of complex II (succinate-ubiquinone oxidoreductase) in mitochondria from the parasitic nematode, Ascaris suum (1995), J. Biol. Chem., 270, 928-932.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-Thenoyltrifluoroacetone 15% inhibition of succinate dehydrogenase activity of larval and adult complex II at 0.1 mM Ascaris suum
carboxin 15% inhibition of succinate dehydrogenase activity of larval and adult complex II at 0.001 mM Ascaris suum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.003
-
ubiquinone-1 larval and adult complex II Ascaris suum
0.143
-
fumarate complex II from adult nematode Ascaris suum
0.153
-
succinate complex II from larvae Ascaris suum
0.455
-
fumarate complex II from larvae Ascaris suum
0.608
-
succinate complex II from adult nematode Ascaris suum

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion of the adult parasitic nematode and of free living second stage larvae Ascaris suum 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
120000
-
larval and adult complex II, non-denaturating PAGE Ascaris suum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Ascaris suum complex II from mitochondria of the adult parasitic nematode exhibits a high fumarate reductase activity and plays a key role in the anaerobic electron transport observed in these organelles ?
-
?
succinate + ubiquinone Ascaris suum
-
fumarate + ubiquinol
-
?

Organism

Organism UniProt Comment Textmining
Ascaris suum
-
succinate dehydrogenase
-
Ascaris suum
-
fumarate reductase
-

Purification (Commentary)

Purification (Comment) Organism
using solubilization with sucrose monolaurate and column chromatography on DEAE-cellulose Ascaris suum

Source Tissue

Source Tissue Comment Organism Textmining
muscle
-
Ascaris suum
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.706
-
complex II from larvae, fumarate reductase activity Ascaris suum
3.53
-
complex II from adult nematode, succinate dehydrogenase activity Ascaris suum
4.28
-
complex II from larvae, succinate dehydrogenase activity Ascaris suum
28.9
-
complex II from adult nematode, fumarate reductase activity Ascaris suum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information fumarate reductase activity of larval complex II is less than 3% of that of adult enzyme, complex II of adult nematode functions in the reverse direction as a fumarate reductase rather than as a succinate dehydrogenase Ascaris suum ?
-
?
additional information complex II from mitochondria of the adult parasitic nematode exhibits a high fumarate reductase activity and plays a key role in the anaerobic electron transport observed in these organelles Ascaris suum ?
-
?
succinate + ubiquinone
-
Ascaris suum fumarate + ubiquinol
-
?
succinate + ubiquinone the succinate dehydrogenase activity of mitochondria in adults and larvae are comparable Ascaris suum fumarate + ubiquinol
-
?