Cloned (Comment) | Organism |
---|---|
cloning of a mutant fumarate reductase operon | Escherichia coli |
Protein Variants | Comment | Organism |
---|---|---|
H82R | menaquinone, ubiquinone and b-type cytochrome levels are present in normal amounts, the mutation alters the electron transfer properties of the iron-sulfur and flavin redox centers of the catalytic domain, functional electron flow from 2,3-dimethyl-1,4-naphthoquinone or from the electron transport chain is impaired, the mutant can be reduced normally by single-electron donors such as benzyl viologen | Escherichia coli |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-(n-heptyl)-4-hydroxy-quinoline N-oxide | - |
Escherichia coli |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
13000 | - |
fumarate reductase, membrane-extrinsic domain: 1 * 69000 + 1 * 27000, membrane-intrinsic domain: 1 * 15000 + 1 * 13000 containing cytochrome b, necessary for converting succinate dehydrogenase EC 1.3.99.1 into succinate-ubiquinone oxidoreductase | Escherichia coli |
15000 | - |
fumarate reductase, membrane-extrinsic domain: 1 * 69000 + 1 * 27000, membrane-intrinsic domain: 1 * 15000 + 1 * 13000 containing cytochrome b, necessary for converting succinate dehydrogenase EC 1.3.99.1 into succinate-ubiquinone oxidoreductase | Escherichia coli |
27000 | - |
fumarate reductase, membrane-extrinsic domain: 1 * 69000 + 1 * 27000, membrane-intrinsic domain: 1 * 15000 + 1 * 13000 containing cytochrome b, necessary for converting succinate dehydrogenase EC 1.3.99.1 into succinate-ubiquinone oxidoreductase | Escherichia coli |
69000 | - |
fumarate reductase, membrane-extrinsic domain: 1 * 69000 + 1 * 27000, membrane-intrinsic domain: 1 * 15000 + 1 * 13000 containing cytochrome b, necessary for converting succinate dehydrogenase EC 1.3.99.1 into succinate-ubiquinone oxidoreductase | Escherichia coli |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
fumarate reductase | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
fumarate + 2,3-dimethyl-1,4-naphthohydroquinone | mutation of His-82 to Arg in fumarate reductase subunit C prevents oxidation of 2,3-dimethyl-1,4-naphthohydroquinone | Escherichia coli | succinate + 2,3-dimethyl-1,4-naphthoquinone | - |
r |
Subunits | Comment | Organism |
---|---|---|
tetramer | fumarate reductase, membrane-extrinsic domain: 1 * 69000 + 1 * 27000, membrane-intrinsic domain: 1 * 15000 + 1 * 13000 containing cytochrome b, necessary for converting succinate dehydrogenase EC 1.3.99.1 into succinate-ubiquinone oxidoreductase | Escherichia coli |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
additional information | the enzyme contains iron-sulfur centers | Escherichia coli |