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Literature summary for 1.3.3.6 extracted from

  • Chu, R.; Varanasi, U.; Chu, S.; Lin, Y.; Usuda, N.; Rao, M.S.; Reddy, J.K.
    Overexpression and characterization of the human peroxisomal acyl-CoA oxidase in insect cells (1995), J. Biol. Chem., 270, 4908-4915.
    View publication on PubMed
Search for more literature for 1.3.3.6

Cloned(Commentary)

Cloned (Comment) Organism
expression as His-tagged protein in Spodoptera frugiperda cells via infection with Baculovirus Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Detergents inactiviation via dissociation of subunits Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.01
-
 palmitoyl-CoA recombinant enzyme from Spodoptera frugiperda cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
peroxisome
-
 Homo sapiens 5777
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
21000
-
 ? * 51000 + ? * 21000, recombinant enzyme, SDS-PAGE Homo sapiens
51000
-
 ? * 51000 + ? * 21000, recombinant enzyme, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acyl-CoA + O2 Homo sapiens involved in beta-oxidation of fatty acids in peroxisomes and glyoxysomes, respectively trans-2,3-dehydroacyl-CoA + H2O2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant His-tagged from Spodoptera frugiperda cells Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyl-CoA + O2 preference for C12-C18 acyl-CoA substrates Homo sapiens trans-2,3-dehydroacyl-CoA + H2O2
-
 ?
acyl-CoA + O2 involved in beta-oxidation of fatty acids in peroxisomes and glyoxysomes, respectively Homo sapiens trans-2,3-dehydroacyl-CoA + H2O2
-
 ?
palmitoyl-CoA + O2
-
 Homo sapiens 2-trans-hexadecenoyl-CoA + H2O2
-
 ?

Subunits

Subunits Comment Organism
? ? * 51000 + ? * 21000, recombinant enzyme, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
ACOX
-
 Homo sapiens
palmitoyl-CoA oxidase
-
 Homo sapiens