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Literature summary for 1.3.3.6 extracted from

  • Osumi, T.; Hashimoto, T.; Ui, N.
    Purification and properties of acyl-CoA oxidase from rat liver (1980), J. Biochem., 87, 1735-1746.
    View publication on PubMed
Search for more literature for 1.3.3.6

Inhibitors

Inhibitors Comment Organism Structure
3-ketohexadecanoyl-CoA
-
 Rattus norvegicus
CH3COOK
-
 Rattus norvegicus
KBr
-
 Rattus norvegicus
KCl
-
 Rattus norvegicus
KI
-
 Rattus norvegicus
KNO3
-
 Rattus norvegicus
NaCl
-
 Rattus norvegicus
NaN3
-
 Rattus norvegicus
NH4Cl
-
 Rattus norvegicus
NH4SCN
-
 Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.005
-
 O2
-
 Rattus norvegicus
0.0073
-
 linoleoyl-CoA
-
 Rattus norvegicus
0.0096
-
 stearoyl-CoA
-
 Rattus norvegicus
0.011
-
 oleoyl-CoA
-
 Rattus norvegicus
0.011
-
 myristoyl-CoA
-
 Rattus norvegicus
0.0116
-
 palmitoyl-CoA
-
 Rattus norvegicus
0.0116
-
 myristoyl-CoA
-
 Rattus norvegicus
0.013
-
 lauroyl-CoA
-
 Rattus norvegicus
0.02
-
 decanoyl-CoA
-
 Rattus norvegicus
0.027
-
 lauroyl-CoA liver enzyme Rattus norvegicus
0.058
-
 octanoyl-CoA
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
peroxisome
-
 Rattus norvegicus 5777
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
139000
-
 sedimentation equilibrium method Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acyl-CoA + O2 Rattus norvegicus involved in beta-oxidation of fatty acids in peroxisomes and glyoxysomes, respectively trans-2,3-dehydroacyl-CoA + H2O2
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.04
-
 purified enzyme Rattus norvegicus

Storage Stability

Storage Stability Organism
-20°C, for at least 1 month Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyl-CoA + O2 3'-phosphate on the ribose ring and the structure of the adenine moiety are essential for substrate recognition, specificity is relatively low with respect to the structure of the pantric acid moiety Rattus norvegicus trans-2,3-dehydroacyl-CoA + H2O2
-
 ?
acyl-CoA + O2 involved in beta-oxidation of fatty acids in peroxisomes and glyoxysomes, respectively Rattus norvegicus trans-2,3-dehydroacyl-CoA + H2O2
-
 ?
decanoyl-CoA + O2
-
 Rattus norvegicus trans-2-decenoyl-CoA + H2O2
-
 ?
lauroyl-CoA + O2
-
 Rattus norvegicus trans-2-dodecenoyl-CoA + H2O2
-
 ?
linoleoyl-CoA + O2
-
 Rattus norvegicus 2-trans-9-trans-12-trans-octadecatrienoyl-CoA + H2O2
-
 ?
myristoyl-CoA + O2
-
 Rattus norvegicus trans-2-tetradecenoyl-CoA + H2O2
-
 ?
octanoyl-CoA + O2
-
 Rattus norvegicus trans-2-octenoyl-CoA + H2O2
-
 ?
oleoyl-CoA + O2
-
 Rattus norvegicus 2-trans-9-trans-octadecendienoyl-CoA + H2O2
-
 ?
palmitoyl-CoA + O2
-
 Rattus norvegicus 2-trans-hexadecenoyl-CoA + H2O2
-
 ?
stearoyl-CoA + O2
-
 Rattus norvegicus trans-2-octadecenoyl-CoA + H2O2
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
-
 Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
7 10 pH 7: about 30% of activity maximum, pH 10: about 5% of activity maximum, inactive below pH 6.5 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
FAD prosthetic group Rattus norvegicus
FAD flavoprotein Rattus norvegicus
FAD 1.22 mol per mol of enzyme Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00047
-
 3-ketohexadecanoyl-CoA
-
 Rattus norvegicus