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Literature summary for 1.3.3.4 extracted from
- Insight into the structural requirements of protoporphyrinogen oxidase inhibitors molecular docking and CoMFA of diphenyl ether, isoxazole phenyl, and pyrazole phenyl ether (2013), Chin. J. Chem., 31, 1153-1158 .
No PubMed abstract available
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene PPX2, recombinant expression in Escherichia coli strain BL21(DE3)-pLysS | Nicotiana tabacum |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1-nitro-4-phenoxybenzene | - |
Nicotiana tabacum |  |
| 2-chloro-4-[4-[chloro(difluoro)methyl]-3-[(prop-2-yn-1-yl)oxy]phenyl]furan-3-carboxamide | - |
Nicotiana tabacum | |
| 2-chloro-4-[4-[chloro(difluoro)methyl]phenyl]furan-3-carbonyl chloride | - |
Nicotiana tabacum | |
| 2-chloro-4-[4-[chloro(difluoro)methyl]phenyl]furan-3-carboxamide | - |
Nicotiana tabacum | |
| 2-[5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrophenoxy]furan | - |
Nicotiana tabacum | |
| 5-[2-chloro-5-(trifluoromethyl)phenoxy]-2-nitrobenzoic acid | - |
Nicotiana tabacum | |
| acifluorfen | - |
Nicotiana tabacum | |
| benzofluorfen | - |
Nicotiana tabacum | |
| ethyl 2-[5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrophenoxy]propanoate | - |
Nicotiana tabacum | |
| ethyl N-(2-bromo-4-[4-[chloro(difluoro)methyl]phenyl]furan-3-carbonyl)alaninate | - |
Nicotiana tabacum | |
| ethyl N-(2-chloro-4-[4-[chloro(difluoro)methyl]phenyl]furan-3-carbonyl)alaninate | - |
Nicotiana tabacum | |
| fluorodifen | - |
Nicotiana tabacum | |
| fomesafen | - |
Nicotiana tabacum | |
| lactofen | - |
Nicotiana tabacum | |
| methyl 2-chloro-5-[2-chloro-4-(trifluoromethyl)phenoxy]benzoate | - |
Nicotiana tabacum | |
| methyl 4-[4-[chloro(difluoro)methyl]phenyl]-2-(trifluoromethyl)furan-3-carboxylate | - |
Nicotiana tabacum | |
| methyl 5-[2-chloro-4-(trifluoromethyl)benzene-1-sulfinyl]-2-nitrobenzoate | - |
Nicotiana tabacum | |
| methyl 5-[2-chloro-4-(trifluoromethyl)benzene-1-sulfonyl]-2-nitrobenzoate | - |
Nicotiana tabacum | |
| methyl 5-[2-chloro-5-(trifluoromethyl)phenoxy]-2-nitrobenzoate | - |
Nicotiana tabacum | |
| methyl 5-[[2-chloro-4-(trifluoromethyl)phenyl]sulfanyl]-2-nitrobenzoate | - |
Nicotiana tabacum | |
| methyl [[(E)-(1-[5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrophenyl]ethylidene)amino]oxy]acetate | - |
Nicotiana tabacum | |
| additional information | protoporphyrinogen oxidase is one of the most significant targets for a large family of inhibitors that may be used as herbicide, bactericide, fungicide, or photosensitizing activator to treat cancer through photodynamic therapy (PDT). Molecular docking and comparative molecular field analysis (CoMFA), a three-dimensional quantitative structure-activity relationship technique, are combined in a multistep framework for identifying important factor contributing to activity of PPO inhibitors, the crystal structure of tobacco mitochondrial PPO (mtPPO) is used as template, and all compounds are docked into the enzyme active site, 3D-QSAR model for PPO inhibition activity, overview | Nicotiana tabacum | |
| N2-(5-[[4-chloro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl]oxy]-2-nitrophenyl)-N-methylleucinamide | - |
Nicotiana tabacum | |
| N2-(5-[[4-chloro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl]oxy]-2-nitrophenyl)-N-methylnorleucinamide | - |
Nicotiana tabacum | |
| nitrofen | - |
Nicotiana tabacum | |
| nitrofluorfen | - |
Nicotiana tabacum | |
| oxyfluorfen | - |
Nicotiana tabacum | |
| [[(E)-(1-[5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrophenyl]ethylidene)amino]oxy]acetic acid | - |
Nicotiana tabacum | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Nicotiana tabacum | 5739 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| protoporphyrinogen IX + 3 O2 | Nicotiana tabacum | - |
protoporphyrin IX + 3 H2O2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Nicotiana tabacum | O24164 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| protoporphyrinogen IX + 3 O2 | - |
Nicotiana tabacum | protoporphyrin IX + 3 H2O2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| mtPPO | - |
Nicotiana tabacum |
| PPO | - |
Nicotiana tabacum |
| PPX2 | - |
Nicotiana tabacum |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Nicotiana tabacum |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | - |
Nicotiana tabacum | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.00001 | - |
pH 7.4, temperature not specified in the publication | Nicotiana tabacum | [[(E)-(1-[5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrophenyl]ethylidene)amino]oxy]acetic acid | |
| 0.000012 | - |
pH 7.4, temperature not specified in the publication | Nicotiana tabacum | N2-(5-[[4-chloro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl]oxy]-2-nitrophenyl)-N-methylnorleucinamide | |
| 0.000014 | - |
pH 7.4, temperature not specified in the publication | Nicotiana tabacum | 2-[5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrophenoxy]furan | |
| 0.000014 | - |
pH 7.4, temperature not specified in the publication | Nicotiana tabacum | methyl [[(E)-(1-[5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrophenyl]ethylidene)amino]oxy]acetate | |
| 0.000015 | - |
pH 7.4, temperature not specified in the publication | Nicotiana tabacum | N2-(5-[[4-chloro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl]oxy]-2-nitrophenyl)-N-methylleucinamide | |
| 0.000019 | - |
pH 7.4, temperature not specified in the publication | Nicotiana tabacum | acifluorfen | |
| 0.000022 | - |
pH 7.4, temperature not specified in the publication | Nicotiana tabacum | 2-chloro-4-[4-[chloro(difluoro)methyl]-3-[(prop-2-yn-1-yl)oxy]phenyl]furan-3-carboxamide | |
| 0.000027 | - |
pH 7.4, temperature not specified in the publication | Nicotiana tabacum | N2-(5-[[4-chloro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl]oxy]-2-nitrophenyl)-N-methylleucinamide | |
| 0.000027 | - |
pH 7.4, temperature not specified in the publication | Nicotiana tabacum | N2-(5-[[4-chloro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl]oxy]-2-nitrophenyl)-N-methylnorleucinamide | |
| 0.000031 | - |
pH 7.4, temperature not specified in the publication | Nicotiana tabacum | fomesafen | |
| 0.000032 | - |
pH 7.4, temperature not specified in the publication | Nicotiana tabacum | benzofluorfen | |
| 0.000048 | - |
pH 7.4, temperature not specified in the publication | Nicotiana tabacum | methyl 5-[[2-chloro-4-(trifluoromethyl)phenyl]sulfanyl]-2-nitrobenzoate | |
| 0.000053 | - |
pH 7.4, temperature not specified in the publication | Nicotiana tabacum | methyl 2-chloro-5-[2-chloro-4-(trifluoromethyl)phenoxy]benzoate | |
| 0.000054 | - |
pH 7.4, temperature not specified in the publication | Nicotiana tabacum | oxyfluorfen | |
| 0.000057 | - |
pH 7.4, temperature not specified in the publication | Nicotiana tabacum | ethyl 2-[5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrophenoxy]propanoate | |
| 0.000061 | - |
pH 7.4, temperature not specified in the publication | Nicotiana tabacum | 2-chloro-4-[4-[chloro(difluoro)methyl]phenyl]furan-3-carboxamide | |
| 0.000062 | - |
pH 7.4, temperature not specified in the publication | Nicotiana tabacum | lactofen | |
| 0.00007 | - |
pH 7.4, temperature not specified in the publication | Nicotiana tabacum | acifluorfen | |
| 0.00007 | - |
pH 7.4, temperature not specified in the publication | Nicotiana tabacum | nitrofluorfen | |
| 0.000147 | - |
pH 7.4, temperature not specified in the publication | Nicotiana tabacum | fluorodifen | |
| 0.000199 | - |
pH 7.4, temperature not specified in the publication | Nicotiana tabacum | ethyl N-(2-bromo-4-[4-[chloro(difluoro)methyl]phenyl]furan-3-carbonyl)alaninate | |
| 0.000357 | - |
pH 7.4, temperature not specified in the publication | Nicotiana tabacum | ethyl N-(2-chloro-4-[4-[chloro(difluoro)methyl]phenyl]furan-3-carbonyl)alaninate | |
| 0.000406 | - |
pH 7.4, temperature not specified in the publication | Nicotiana tabacum | nitrofen | |
| 0.000599 | - |
pH 7.4, temperature not specified in the publication | Nicotiana tabacum | methyl 4-[4-[chloro(difluoro)methyl]phenyl]-2-(trifluoromethyl)furan-3-carboxylate | |
| 0.00222 | - |
pH 7.4, temperature not specified in the publication | Nicotiana tabacum | methyl 5-[2-chloro-5-(trifluoromethyl)phenoxy]-2-nitrobenzoate | |
| 0.00558 | - |
pH 7.4, temperature not specified in the publication | Nicotiana tabacum | 2-chloro-4-[4-[chloro(difluoro)methyl]phenyl]furan-3-carbonyl chloride | |
| 0.01254 | - |
pH 7.4, temperature not specified in the publication | Nicotiana tabacum | methyl 5-[2-chloro-4-(trifluoromethyl)benzene-1-sulfinyl]-2-nitrobenzoate | |
| 0.02279 | - |
pH 7.4, temperature not specified in the publication | Nicotiana tabacum | ethyl 2-[5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrophenoxy]propanoate | |
| 0.02616 | - |
pH 7.4, temperature not specified in the publication | Nicotiana tabacum | 5-[2-chloro-5-(trifluoromethyl)phenoxy]-2-nitrobenzoic acid | |
| 0.03963 | - |
pH 7.4, temperature not specified in the publication | Nicotiana tabacum | 1-nitro-4-phenoxybenzene | |
| 0.0474 | - |
pH 7.4, temperature not specified in the publication | Nicotiana tabacum | methyl 5-[2-chloro-4-(trifluoromethyl)benzene-1-sulfonyl]-2-nitrobenzoate | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | protoporphyrinogen oxidase (PPO) is a key enzyme in the tetrapyrrole biosynthesis | Nicotiana tabacum |
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