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Literature summary for 1.3.3.3 extracted from

  • Yoshinaga, T.
    Purification and properties of coproporphyrinogen III oxidase from bovine liver (1997), Methods Enzymol., 281, 355-367.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
2-mercaptoethanol slight activation Bos taurus
DTT slight activation Bos taurus
lecithin 2fold activation Mus musculus
Non-ionic detergents 2fold activation Mus musculus
Non-ionic detergents 2-4fold activation Bos taurus
Phospholipids 2-4fold activation Bos taurus

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Mus musculus

Protein Variants

Protein Variants Comment Organism
H158A complete loss of activity, decreased stability, no copper content Mus musculus

General Stability

General Stability Organism
tends to aggregate during prolonged storage at 4°C Mus musculus
tends to aggregate during prolonged storage at 4°C Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
additional information decreased activity at high ionic strength Bos taurus
SDS inhibitory Bos taurus
sodium deoxycholate inhibitory Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.047
-
Coproporphyrinogen-III
-
Mus musculus
0.048
-
Coproporphyrinogen-III
-
Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Mus musculus 5739
-
mitochondrion located within intermembrane space Bos taurus 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
Cu2+ 0.06 atom per enzyme Bos taurus
Cu2+ 1.05 atoms per enzyme Mus musculus
Fe2+ 0.07-0.14 atom per enzyme Bos taurus
Fe2+ trace amounts Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
37000
-
x * 37000, SDS-PAGE Mus musculus
37000
-
x * 37000, SDS-PAGE Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
coproporphyrinogen-III + O2 + 2 H+ Bos taurus
-
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
?
coproporphyrinogen-III + O2 + 2 H+ Mus musculus 6th enzyme in heme biosynthetic pathway protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Mus musculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
to homogeneity, chromatography steps Bos taurus
to homogeneity, recombinant enzyme Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Mus musculus
-
liver
-
Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.3
-
-
Mus musculus
0.7
-
-
Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
coproporphyrinogen-III + O2 + 2 H+
-
Bos taurus protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
?
coproporphyrinogen-III + O2 + 2 H+ sixths enzyme in heme biosynthetic pathway Mus musculus protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
?
coproporphyrinogen-III + O2 + 2 H+ 6th enzyme in heme biosynthetic pathway Mus musculus protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
?

Subunits

Subunits Comment Organism
? x * 37000, SDS-PAGE Mus musculus
? x * 37000, SDS-PAGE Bos taurus