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Literature summary for 1.3.3.15 extracted from

  • Surdel, M.C.; Horvath, D.J.; Lojek, L.J.; Fullen, A.R.; Simpson, J.; Dutter, B.F.; Salleng, K.J.; Ford, J.B.; Jenkins, J.L.; Nagarajan, R.; Teixeira, P.L.; Albertolle, M.; Georgiev, I.S.; Jansen, E.D.; Sulikowski, G.A.; Lacy, D.B.; Dailey, H.A.; Skaar, E.P.
    Antibacterial photosensitization through activation of coproporphyrinogen oxidase (2017), Proc. Natl. Acad. Sci. USA, 114, E6652-E6659 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.3.3.15

Activating Compound

Activating Compound Comment Organism Structure
2-[3-(furan-2-yl)-1H-pyrazol-5-yl]naphthalen-1-ol i.e. VU0038882 Bacillus subtilis
2-[3-(furan-2-yl)-1H-pyrazol-5-yl]naphthalen-1-ol i.e. VU0038882 Staphylococcus epidermidis
2-[3-(furan-2-yl)-1H-pyrazol-5-yl]naphthalen-1-ol i.e. VU0038882 Staphylococcus haemolyticus
2-[3-(furan-2-yl)-1H-pyrazol-5-yl]naphthalen-1-ol i.e. VU0038882 Cutibacterium acnes
2-[3-(furan-2-yl)-1H-pyrazol-5-yl]naphthalen-1-ol i.e. VU0038882 Bacillus anthracis
2-[3-(furan-2-yl)-1H-pyrazol-5-yl]naphthalen-1-ol i.e. VU0038882 Staphylococcus lugdunensis
2-[3-(furan-2-yl)-1H-pyrazol-5-yl]naphthalen-1-ol i.e. VU0038882, 204.8% activity at 0.01 mM Staphylococcus aureus

Protein Variants

Protein Variants Comment Organism
F187W the mutation inhibits the activation of the enzyme by VU0038882 Staphylococcus aureus
M167F the mutation inhibits the activation of the enzyme by VU0038882 Staphylococcus aureus
N186F the mutant exhibits increased baseline activity relative to the wild type enzyme Staphylococcus aureus
N186Y the mutant exhibits increased baseline activity relative to the wild type enzyme Staphylococcus aureus
T183K the mutation does not restrict enzyme function. The mutant does not respond to VU0038882 at concentrations up to 0.01 mM Staphylococcus aureus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
coproporphyrinogen III + 3 O2 Staphylococcus aureus
-
 coproporphyrin III + 3 H2O2
-
 ?
coproporphyrinogen III + 3 O2 Bacillus subtilis
-
 coproporphyrin III + 3 H2O2
-
 ?
coproporphyrinogen III + 3 O2 Staphylococcus epidermidis
-
 coproporphyrin III + 3 H2O2
-
 ?
coproporphyrinogen III + 3 O2 Staphylococcus haemolyticus
-
 coproporphyrin III + 3 H2O2
-
 ?
coproporphyrinogen III + 3 O2 Cutibacterium acnes
-
 coproporphyrin III + 3 H2O2
-
 ?
coproporphyrinogen III + 3 O2 Bacillus anthracis
-
 coproporphyrin III + 3 H2O2
-
 ?
coproporphyrinogen III + 3 O2 Staphylococcus lugdunensis
-
 coproporphyrin III + 3 H2O2
-
 ?
coproporphyrinogen III + 3 O2 Staphylococcus aureus USA300
-
 coproporphyrin III + 3 H2O2
-
 ?

Organism

Organism UniProt Comment Textmining
Bacillus anthracis
-
-
-
Bacillus subtilis
-
-
-
Cutibacterium acnes
-
-
-
Staphylococcus aureus
-
-
-
Staphylococcus aureus USA300
-
-
-
Staphylococcus epidermidis
-
-
-
Staphylococcus haemolyticus
-
-
-
Staphylococcus lugdunensis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
coproporphyrinogen III + 3 O2
-
 Staphylococcus aureus coproporphyrin III + 3 H2O2
-
 ?
coproporphyrinogen III + 3 O2
-
 Bacillus subtilis coproporphyrin III + 3 H2O2
-
 ?
coproporphyrinogen III + 3 O2
-
 Staphylococcus epidermidis coproporphyrin III + 3 H2O2
-
 ?
coproporphyrinogen III + 3 O2
-
 Staphylococcus haemolyticus coproporphyrin III + 3 H2O2
-
 ?
coproporphyrinogen III + 3 O2
-
 Cutibacterium acnes coproporphyrin III + 3 H2O2
-
 ?
coproporphyrinogen III + 3 O2
-
 Bacillus anthracis coproporphyrin III + 3 H2O2
-
 ?
coproporphyrinogen III + 3 O2
-
 Staphylococcus lugdunensis coproporphyrin III + 3 H2O2
-
 ?
coproporphyrinogen III + 3 O2
-
 Staphylococcus aureus USA300 coproporphyrin III + 3 H2O2
-
 ?

Synonyms

Synonyms Comment Organism
CgoX formally known as HemY Staphylococcus aureus
CgoX formally known as HemY Bacillus subtilis
CgoX formally known as HemY Staphylococcus epidermidis
CgoX formally known as HemY Staphylococcus haemolyticus
CgoX formally known as HemY Cutibacterium acnes
CgoX formally known as HemY Bacillus anthracis
CgoX formally known as HemY Staphylococcus lugdunensis

General Information

General Information Comment Organism
metabolism the enzyme is required for heme biosynthesis Staphylococcus aureus
metabolism the enzyme is required for heme biosynthesis Bacillus subtilis
metabolism the enzyme is required for heme biosynthesis Staphylococcus epidermidis
metabolism the enzyme is required for heme biosynthesis Staphylococcus haemolyticus
metabolism the enzyme is required for heme biosynthesis Cutibacterium acnes
metabolism the enzyme is required for heme biosynthesis Bacillus anthracis
metabolism the enzyme is required for heme biosynthesis Staphylococcus lugdunensis