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Literature summary for 1.3.1.98 extracted from

  • Matsuo, M.; Kurokawa, K.; Nishida, S.; Li, Y.; Takimura, H.; Kaito, C.; Fukuhara, N.; Maki, H.; Miura, K.; Murakami, K.; Sekimizu, K.
    Isolation and mutation site determination of the temperature-sensitive murB mutants of Staphylococcus aureus (2003), FEMS Microbiol. Lett., 222, 107-113.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli and in host strain Staphylococcus aureus

Protein Variants

Protein Variants Comment Organism
E275K strong decrease in enzyme activity, thinner cell walls than wild type strain Staphylococcus aureus
G251D strong decrease in enzyme activity, thinner cell walls than wild type strain Staphylococcus aureus
G78D strong decrease in enzyme activity, thinner cell walls than wild type strain Staphylococcus aureus
S243F strong decrease in enzyme activity, thinner cell walls than wild type strain Staphylococcus aureus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH Staphylococcus aureus essential for cell growth, functions in bacterial peptidoglycan biosynthesis UDP-N-acetyl-3-D-muramate + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus Q54A20
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH
-
Staphylococcus aureus UDP-N-acetyl-3-D-muramate + NADP+
-
?
UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH essential for cell growth, functions in bacterial peptidoglycan biosynthesis Staphylococcus aureus UDP-N-acetyl-3-D-muramate + NADP+
-
?

Cofactor

Cofactor Comment Organism Structure
FAD bound to protein Staphylococcus aureus
NADPH
-
Staphylococcus aureus