Literature summary for 1.3.1.92 extracted from

Bertea, C.; Freije, J.; Van Der Woude, H.; Verstappen, F.; Perk, L.; Marquez, V.; De Kraker, J.; Posthumus, M.; Jansen, B.; De Groot, A.; Franssen, M.; Bouwmeester, H.
Identification of intermediates and enzymes involved in the early steps of artemisinin biosynthesis in Artemisia annua (2005), Planta Med., 71, 40-47.

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Organism

Organism	UniProt	Comment	Textmining
Artemisia annua	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
leaf	presence of a number of biosynthetic enzymes such as the amorpha-4,11-diene synthase and the amorpha-4,11-diene hydroxylase as well as artemisinic alcohol and dihydroartemisinic aldehyde dehydrogenase activities in both leaves and glandular trichomes	Artemisia annua	-
trichome	glandular trichome, presence of a number of biosynthetic enzymes such as the amorpha-4,11-diene synthase and the amorpha-4,11-diene hydroxylase as well as artemisinic alcohol and dihydroartemisinic aldehyde dehydrogenase activities in both leaves and glandular trichomes	Artemisia annua	-

General Information

General Information	Comment	Organism
physiological function	the early steps in artemisinin biosynthesis involve amorpha-4,11-diene hydroxylation to artemisinic alcohol, followed by oxidation to artemisinic aldehyde, reduction of the C11-C13 double bond to dihydroartemisinic aldehyde and oxidation to dihydroartemisinic acid	Artemisia annua

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Release 2023.1 (January 2023)