Cloned (Comment) | Organism |
---|---|
- |
Plasmodium falciparum |
Crystallization (Comment) | Organism |
---|---|
in complex with NADH and inhibitors, hanging drop vapor diffusion method | Plasmodium falciparum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-(4-(4-chloro-2-hydroxyphenoxy)phenyl)-7-hydroxy-2H-chromen-2-one | - |
Plasmodium falciparum | |
3-(4-chloro-2-hydroxyphenoxy)-4-methyl-2H-chromen-2-one | - |
Plasmodium falciparum | |
3-(4-chloro-2-hydroxyphenoxy)-5,7-dihydroxy-2H-chromen-2-one | - |
Plasmodium falciparum | |
3-(4-chloro-2-hydroxyphenoxy)-6-hydroxy-2H-chromen-2-one | - |
Plasmodium falciparum | |
3-(4-chloro-2-hydroxyphenoxy)-7-hydroxy-2H-chromen-2-one | - |
Plasmodium falciparum | |
3-(4-chloro-2-hydroxyphenoxy)-7-hydroxy-4-methyl-2H-chromen-2-one | - |
Plasmodium falciparum | |
6-(4-chloro-2-hydroxyphenoxy)-2H-chromen-2-one | - |
Plasmodium falciparum | |
6-(4-chloro-2-hydroxyphenoxy)-4-ethyl-2H-chromen-2-one | - |
Plasmodium falciparum | |
6-(4-chloro-2-hydroxyphenoxy)-4-methyl-2H-chromen-2-one | - |
Plasmodium falciparum | |
6-(4-chloro-2-hydroxyphenoxy)naphthalen-2-ol | - |
Plasmodium falciparum | |
7-(4-chloro-2-hydroxyphenoxy)-2H-chromen-2-one | - |
Plasmodium falciparum | |
7-(4-chloro-2-hydroxyphenoxy)-4-ethyl-2H-chromen-2-one | - |
Plasmodium falciparum | |
7-(4-chloro-2-hydroxyphenoxy)-4-methyl-2H-chromen-2-one | - |
Plasmodium falciparum | |
additional information | not inhibited by (-)-epigallocatechin gallate, chloroquine, and podophyllotoxin | Plasmodium falciparum | |
triclosan | i.e. 5-chloro-2-(2,4-dichlorophenoxy)phenol | Plasmodium falciparum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
trans-2-enoyl-[acyl-carrier protein] + NADH + H+ | Plasmodium falciparum | - |
acyl-[acyl-carrier protein] + NAD+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Plasmodium falciparum | C6KSZ2 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Plasmodium falciparum |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
trans-2-enoyl-[acyl-carrier protein] + NADH + H+ | - |
Plasmodium falciparum | acyl-[acyl-carrier protein] + NAD+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
enoyl-ACP reductase | - |
Plasmodium falciparum |
enoyl-acyl carrier protein reductase | - |
Plasmodium falciparum |
ENR | - |
Plasmodium falciparum |
FabI | - |
Plasmodium falciparum |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | - |
Plasmodium falciparum |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00005 | - |
pH and temperature not specified in the publication | Plasmodium falciparum | triclosan |