Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.3.1.9 extracted from

  • Kim, Y.G.; Seo, J.H.; Kwak, J.H.; Shin, K.J.
    Discovery of a potent enoyl-acyl carrier protein reductase (FabI) inhibitor suitable for antistaphylococcal agent (2015), Bioorg. Med. Chem. Lett., 25, 4481-4486.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1-butyl-5-(2,4-dichlorophenoxy)-2-(phenoxymethyl)pyridin-4(1H)-one
-
Staphylococcus aureus
1-butyl-5-(2,4-dimethylphenoxy)-2-(phenoxymethyl)pyridin-4(1H)-one
-
Staphylococcus aureus
1-butyl-5-(4-chloro-2-methylphenoxy)-2-(phenoxymethyl)pyridin-4(1H)-one
-
Staphylococcus aureus
1-cyclopropyl-5-(2,3-dichlorophenoxy)-2-(phenoxymethyl)pyridin-4(1H)-one
-
Staphylococcus aureus
1-cyclopropyl-5-(2,4-dichlorophenoxy)-2-(phenoxymethyl)pyridin-4(1H)-one
-
Staphylococcus aureus
1-cyclopropyl-5-(2,4-dimethylphenoxy)-2-(phenoxymethyl)pyridin-4(1H)-one
-
Staphylococcus aureus
1-cyclopropyl-5-(2,6-dichlorophenoxy)-2-(phenoxymethyl)pyridin-4(1H)-one
-
Staphylococcus aureus
5-(2,3-dichlorophenoxy)-1-methyl-2-(phenoxymethyl)pyridin-4(1H)-one
-
Staphylococcus aureus
5-(2,3-dichlorophenoxy)-2-(phenoxymethyl)-4H-pyran-4-one
-
Staphylococcus aureus
5-(2,3-dichlorophenoxy)-2-(phenoxymethyl)pyridin-4(1H)-one
-
Staphylococcus aureus
5-(2,3-dichlorophenoxy)-2-[(E)-2-(furan-3-yl)ethenyl]-4H-pyran-4-one
-
Staphylococcus aureus
5-(2,3-dichlorophenoxy)-2-[(E)-2-(pyridin-3-yl)ethenyl]-4H-pyran-4-one
-
Staphylococcus aureus
5-(2,3-dichlorophenoxy)-2-[(E)-2-phenylethenyl]-4H-pyran-4-one
-
Staphylococcus aureus
5-(2,4-dichlorophenoxy)-1-methyl-2-(phenoxymethyl)pyridin-4(1H)-one
-
Staphylococcus aureus
5-(2,4-dichlorophenoxy)-2-(phenoxymethyl)-1-phenylpyridin-4(1H)-one
-
Staphylococcus aureus
5-(2,4-dichlorophenoxy)-2-(phenoxymethyl)-4H-pyran-4-one
-
Staphylococcus aureus
5-(2,4-dichlorophenoxy)-2-(phenoxymethyl)pyridin-4(1H)-one
-
Staphylococcus aureus
5-(2,4-dichlorophenoxy)-2-[(E)-2-(furan-3-yl)ethenyl]-4H-pyran-4-one
-
Staphylococcus aureus
5-(2,4-dichlorophenoxy)-2-[(E)-2-(pyridin-3-yl)ethenyl]-4H-pyran-4-one
-
Staphylococcus aureus
5-(2,4-dichlorophenoxy)-2-[(E)-2-phenylethenyl]-4H-pyran-4-one
-
Staphylococcus aureus
5-(2,4-dimethylphenoxy)-1-methyl-2-(phenoxymethyl)pyridin-4(1H)-one
-
Staphylococcus aureus
5-(2,4-dimethylphenoxy)-2-(phenoxymethyl)-1-phenylpyridin-4(1H)-one
-
Staphylococcus aureus
5-(2,4-dimethylphenoxy)-2-(phenoxymethyl)-4H-pyran-4-one
-
Staphylococcus aureus
5-(2,4-dimethylphenoxy)-2-(phenoxymethyl)pyridin-4(1H)-one
-
Staphylococcus aureus
5-(2,4-dimethylphenoxy)-2-[(E)-2-(furan-3-yl)ethenyl]-4H-pyran-4-one
-
Staphylococcus aureus
5-(2,4-dimethylphenoxy)-2-[(E)-2-(pyridin-3-yl)ethenyl]-4H-pyran-4-one
-
Staphylococcus aureus
5-(2,4-dimethylphenoxy)-2-[(E)-2-phenylethenyl]-4H-pyran-4-one
-
Staphylococcus aureus
5-(2,6-dichlorophenoxy)-1-methyl-2-(phenoxymethyl)pyridin-4(1H)-one
-
Staphylococcus aureus
5-(2,6-dichlorophenoxy)-2-(phenoxymethyl)-4H-pyran-4-one
-
Staphylococcus aureus
5-(2,6-dichlorophenoxy)-2-(phenoxymethyl)pyridin-4(1H)-one
-
Staphylococcus aureus
5-(2,6-dichlorophenoxy)-2-[(E)-2-(furan-3-yl)ethenyl]-4H-pyran-4-one
-
Staphylococcus aureus
5-(2,6-dichlorophenoxy)-2-[(E)-2-(pyridin-3-yl)ethenyl]-4H-pyran-4-one
-
Staphylococcus aureus
5-(2,6-dichlorophenoxy)-2-[(E)-2-phenylethenyl]-4H-pyran-4-one
-
Staphylococcus aureus
5-(2-chloro-3-nitrophenoxy)-1-cyclopropyl-2-(phenoxymethyl)pyridin-4(1H)-one
-
Staphylococcus aureus
5-(2-chloro-3-nitrophenoxy)-1-methyl-2-(phenoxymethyl)pyridin-4(1H)-one
-
Staphylococcus aureus
5-(2-chloro-3-nitrophenoxy)-2-(phenoxymethyl)pyridin-4(1H)-one
-
Staphylococcus aureus
5-(2-methyl-3-nitrophenoxy)-2-(phenoxymethyl)-4H-pyran-4-one
-
Staphylococcus aureus
5-(4-chloro-2-methylphenoxy)-1-cyclopropyl-2-(phenoxymethyl)pyridin-4(1H)-one
-
Staphylococcus aureus
5-(4-chloro-2-methylphenoxy)-1-methyl-2-(phenoxymethyl)pyridin-4(1H)-one
-
Staphylococcus aureus
5-(4-chloro-2-methylphenoxy)-2-(phenoxymethyl)-1-phenylpyridin-4(1H)-one
-
Staphylococcus aureus
5-(4-chloro-2-methylphenoxy)-2-(phenoxymethyl)-4H-pyran-4-one
-
Staphylococcus aureus
5-(4-chloro-2-methylphenoxy)-2-(phenoxymethyl)pyridin-4(1H)-one
-
Staphylococcus aureus
5-(4-chloro-2-methylphenoxy)-2-[(1E)-3-methylbut-1-en-1-yl]-4H-pyran-4-one
-
Staphylococcus aureus
5-(4-chloro-2-methylphenoxy)-2-[(1E)-pent-1-en-1-yl]-4H-pyran-4-one
-
Staphylococcus aureus
5-(4-chloro-2-methylphenoxy)-2-[(E)-2-(1H-pyrrol-2-yl)ethenyl]-4H-pyran-4-one
-
Staphylococcus aureus
5-(4-chloro-2-methylphenoxy)-2-[(E)-2-(furan-2-yl)ethenyl]-4H-pyran-4-one
-
Staphylococcus aureus
5-(4-chloro-2-methylphenoxy)-2-[(E)-2-(furan-3-yl)ethenyl]-4H-pyran-4-one
-
Staphylococcus aureus
5-(4-chloro-2-methylphenoxy)-2-[(E)-2-(pyridin-3-yl)ethenyl]-4H-pyran-4-one
-
Staphylococcus aureus
5-(4-chloro-2-methylphenoxy)-2-[(E)-2-(thiophen-2-yl)ethenyl]-4H-pyran-4-one
-
Staphylococcus aureus
5-(4-chloro-2-methylphenoxy)-2-[(E)-2-(thiophen-3-yl)ethenyl]-4H-pyran-4-one
-
Staphylococcus aureus
5-(4-chloro-2-methylphenoxy)-2-[(E)-2-phenylethenyl]-4H-pyran-4-one
-
Staphylococcus aureus
5-(4-chlorophenoxy)-2-(methoxymethyl)-4H-pyran-4-one
-
Staphylococcus aureus
isoniazid
-
Staphylococcus aureus
linezolid
-
Staphylococcus aureus
triclosan
-
Staphylococcus aureus

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
-
-
-
Staphylococcus aureus MRSA
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
trans-2-octenoyl N-acetylcysteamine + NADH + H+
-
Staphylococcus aureus ?
-
?
trans-2-octenoyl N-acetylcysteamine + NADH + H+
-
Staphylococcus aureus MRSA ?
-
?

Synonyms

Synonyms Comment Organism
enoyl-ACP reductase
-
Staphylococcus aureus
enoyl-acyl carrier protein reductase
-
Staphylococcus aureus
FabI
-
Staphylococcus aureus

Cofactor

Cofactor Comment Organism Structure
NADH
-
Staphylococcus aureus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00008
-
at pH 6.5 and 30°C Staphylococcus aureus 5-(2,4-dimethylphenoxy)-1-methyl-2-(phenoxymethyl)pyridin-4(1H)-one
0.00011
-
at pH 6.5 and 30°C Staphylococcus aureus 5-(4-chloro-2-methylphenoxy)-1-methyl-2-(phenoxymethyl)pyridin-4(1H)-one
0.00012
-
at pH 6.5 and 30°C Staphylococcus aureus 5-(2,4-dichlorophenoxy)-1-methyl-2-(phenoxymethyl)pyridin-4(1H)-one
0.00022
-
at pH 6.5 and 30°C Staphylococcus aureus 5-(2,3-dichlorophenoxy)-1-methyl-2-(phenoxymethyl)pyridin-4(1H)-one
0.00038
-
at pH 6.5 and 30°C Staphylococcus aureus 5-(2,4-dimethylphenoxy)-2-(phenoxymethyl)-4H-pyran-4-one
0.0004
-
at pH 6.5 and 30°C Staphylococcus aureus 5-(4-chloro-2-methylphenoxy)-2-(phenoxymethyl)pyridin-4(1H)-one
0.00044
-
at pH 6.5 and 30°C Staphylococcus aureus triclosan
0.00045
-
at pH 6.5 and 30°C Staphylococcus aureus 5-(4-chloro-2-methylphenoxy)-2-(phenoxymethyl)-4H-pyran-4-one
0.00047
-
at pH 6.5 and 30°C Staphylococcus aureus 5-(4-chloro-2-methylphenoxy)-1-cyclopropyl-2-(phenoxymethyl)pyridin-4(1H)-one
0.00048
-
at pH 6.5 and 30°C Staphylococcus aureus 1-cyclopropyl-5-(2,4-dichlorophenoxy)-2-(phenoxymethyl)pyridin-4(1H)-one
0.00063
-
at pH 6.5 and 30°C Staphylococcus aureus 1-butyl-5-(4-chloro-2-methylphenoxy)-2-(phenoxymethyl)pyridin-4(1H)-one
0.00065
-
at pH 6.5 and 30°C Staphylococcus aureus 5-(4-chloro-2-methylphenoxy)-2-(phenoxymethyl)-1-phenylpyridin-4(1H)-one
0.00066
-
at pH 6.5 and 30°C Staphylococcus aureus 5-(2-chloro-3-nitrophenoxy)-1-methyl-2-(phenoxymethyl)pyridin-4(1H)-one
0.00068
-
at pH 6.5 and 30°C Staphylococcus aureus 5-(2,4-dichlorophenoxy)-2-(phenoxymethyl)-4H-pyran-4-one
0.00072
-
at pH 6.5 and 30°C Staphylococcus aureus 5-(2,6-dichlorophenoxy)-1-methyl-2-(phenoxymethyl)pyridin-4(1H)-one
0.00084
-
at pH 6.5 and 30°C Staphylococcus aureus 5-(2,3-dichlorophenoxy)-2-(phenoxymethyl)pyridin-4(1H)-one
0.001
-
at pH 6.5 and 30°C Staphylococcus aureus 1-butyl-5-(2,4-dimethylphenoxy)-2-(phenoxymethyl)pyridin-4(1H)-one
0.00114
-
at pH 6.5 and 30°C Staphylococcus aureus 5-(2,4-dimethylphenoxy)-2-(phenoxymethyl)pyridin-4(1H)-one
0.00125
-
at pH 6.5 and 30°C Staphylococcus aureus 5-(2,3-dichlorophenoxy)-2-(phenoxymethyl)-4H-pyran-4-one
0.00125
-
at pH 6.5 and 30°C Staphylococcus aureus 1-butyl-5-(2,4-dichlorophenoxy)-2-(phenoxymethyl)pyridin-4(1H)-one
0.00142
-
at pH 6.5 and 30°C Staphylococcus aureus 5-(2,6-dichlorophenoxy)-2-(phenoxymethyl)-4H-pyran-4-one
0.00142
-
at pH 6.5 and 30°C Staphylococcus aureus 5-(2,4-dichlorophenoxy)-2-(phenoxymethyl)-1-phenylpyridin-4(1H)-one
0.0015
-
at pH 6.5 and 30°C Staphylococcus aureus 1-cyclopropyl-5-(2,3-dichlorophenoxy)-2-(phenoxymethyl)pyridin-4(1H)-one
0.00182
-
at pH 6.5 and 30°C Staphylococcus aureus 5-(2,4-dichlorophenoxy)-2-(phenoxymethyl)pyridin-4(1H)-one
0.00189
-
at pH 6.5 and 30°C Staphylococcus aureus 5-(2,4-dichlorophenoxy)-2-[(E)-2-(furan-3-yl)ethenyl]-4H-pyran-4-one
0.00204
-
at pH 6.5 and 30°C Staphylococcus aureus 5-(2,4-dichlorophenoxy)-2-[(E)-2-(pyridin-3-yl)ethenyl]-4H-pyran-4-one
0.00229
-
at pH 6.5 and 30°C Staphylococcus aureus 5-(2,4-dimethylphenoxy)-2-[(E)-2-(furan-3-yl)ethenyl]-4H-pyran-4-one
0.00245
-
at pH 6.5 and 30°C Staphylococcus aureus 5-(4-chloro-2-methylphenoxy)-2-[(E)-2-(furan-3-yl)ethenyl]-4H-pyran-4-one
0.00269
-
at pH 6.5 and 30°C Staphylococcus aureus 5-(2,4-dimethylphenoxy)-2-(phenoxymethyl)-1-phenylpyridin-4(1H)-one
0.00294
-
at pH 6.5 and 30°C Staphylococcus aureus 5-(4-chloro-2-methylphenoxy)-2-[(E)-2-(pyridin-3-yl)ethenyl]-4H-pyran-4-one
0.00312
-
at pH 6.5 and 30°C Staphylococcus aureus 5-(4-chloro-2-methylphenoxy)-2-[(E)-2-(thiophen-3-yl)ethenyl]-4H-pyran-4-one
0.00317
-
at pH 6.5 and 30°C Staphylococcus aureus 1-cyclopropyl-5-(2,4-dimethylphenoxy)-2-(phenoxymethyl)pyridin-4(1H)-one
0.00344
-
at pH 6.5 and 30°C Staphylococcus aureus 5-(2,3-dichlorophenoxy)-2-[(E)-2-(pyridin-3-yl)ethenyl]-4H-pyran-4-one
0.00348
-
at pH 6.5 and 30°C Staphylococcus aureus 5-(2,4-dimethylphenoxy)-2-[(E)-2-(pyridin-3-yl)ethenyl]-4H-pyran-4-one
0.00352
-
at pH 6.5 and 30°C Staphylococcus aureus 5-(2-methyl-3-nitrophenoxy)-2-(phenoxymethyl)-4H-pyran-4-one
0.00374
-
at pH 6.5 and 30°C Staphylococcus aureus 5-(2,6-dichlorophenoxy)-2-[(E)-2-(pyridin-3-yl)ethenyl]-4H-pyran-4-one
0.00389
-
at pH 6.5 and 30°C Staphylococcus aureus 5-(4-chloro-2-methylphenoxy)-2-[(E)-2-(furan-2-yl)ethenyl]-4H-pyran-4-one
0.00412
-
at pH 6.5 and 30°C Staphylococcus aureus 5-(2,6-dichlorophenoxy)-2-[(E)-2-(furan-3-yl)ethenyl]-4H-pyran-4-one
0.00453
-
at pH 6.5 and 30°C Staphylococcus aureus 5-(2,4-dichlorophenoxy)-2-[(E)-2-phenylethenyl]-4H-pyran-4-one
0.00457
-
at pH 6.5 and 30°C Staphylococcus aureus 5-(4-chloro-2-methylphenoxy)-2-[(E)-2-(thiophen-2-yl)ethenyl]-4H-pyran-4-one
0.00479
-
at pH 6.5 and 30°C Staphylococcus aureus 5-(2,6-dichlorophenoxy)-2-[(E)-2-phenylethenyl]-4H-pyran-4-one
0.00488
-
at pH 6.5 and 30°C Staphylococcus aureus 5-(4-chloro-2-methylphenoxy)-2-[(E)-2-phenylethenyl]-4H-pyran-4-one
0.00498
-
at pH 6.5 and 30°C Staphylococcus aureus 5-(2,6-dichlorophenoxy)-2-(phenoxymethyl)pyridin-4(1H)-one
0.0052
-
at pH 6.5 and 30°C Staphylococcus aureus 5-(4-chlorophenoxy)-2-(methoxymethyl)-4H-pyran-4-one
0.00533
-
at pH 6.5 and 30°C Staphylococcus aureus 5-(2,4-dimethylphenoxy)-2-[(E)-2-phenylethenyl]-4H-pyran-4-one
0.00568
-
at pH 6.5 and 30°C Staphylococcus aureus 5-(2,3-dichlorophenoxy)-2-[(E)-2-(furan-3-yl)ethenyl]-4H-pyran-4-one
0.00578
-
at pH 6.5 and 30°C Staphylococcus aureus 5-(4-chloro-2-methylphenoxy)-2-[(1E)-3-methylbut-1-en-1-yl]-4H-pyran-4-one
0.00582
-
at pH 6.5 and 30°C Staphylococcus aureus 5-(4-chloro-2-methylphenoxy)-2-[(E)-2-(1H-pyrrol-2-yl)ethenyl]-4H-pyran-4-one
0.00643
-
at pH 6.5 and 30°C Staphylococcus aureus 1-cyclopropyl-5-(2,6-dichlorophenoxy)-2-(phenoxymethyl)pyridin-4(1H)-one
0.00644
-
at pH 6.5 and 30°C Staphylococcus aureus 5-(4-chloro-2-methylphenoxy)-2-[(1E)-pent-1-en-1-yl]-4H-pyran-4-one
0.00673
-
at pH 6.5 and 30°C Staphylococcus aureus 5-(2,3-dichlorophenoxy)-2-[(E)-2-phenylethenyl]-4H-pyran-4-one
0.01173
-
at pH 6.5 and 30°C Staphylococcus aureus 5-(2-chloro-3-nitrophenoxy)-2-(phenoxymethyl)pyridin-4(1H)-one
0.01764
-
at pH 6.5 and 30°C Staphylococcus aureus 5-(2-chloro-3-nitrophenoxy)-1-cyclopropyl-2-(phenoxymethyl)pyridin-4(1H)-one