Literature summary for 1.3.1.9 extracted from

Banerjee, T.; Sharma, S.K.; Surolia, N.; Surolia, A.
Epigallocatechin gallate is a slow-tight binding inhibitor of enoyl-ACP reductase from Plasmodium falciparum (2008), Biochem. Biophys. Res. Commun., 377, 1238-1242.

Search for more literature for 1.3.1.9

Application

Application	Comment	Organism
medicine	epigallocatechin gallate is a promising candidate for the development of tea catechin based antimalarial drugs	Plasmodium falciparum

Cloned(Commentary)

Cloned (Comment)	Organism
-	Plasmodium falciparum

Inhibitors

Inhibitors	Comment	Organism	Structure
epigallocatechin gallate	-	Plasmodium falciparum
triclosan	triclosan lowers the Ki of epigallocatechin gallate	Plasmodium falciparum

Organism

Organism	UniProt	Comment	Textmining
Plasmodium falciparum	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Plasmodium falciparum

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
crotonyl-CoA + NAD+	activity assay	Plasmodium falciparum	butyryl-CoA + NADH + H+	-	?

Synonyms

Synonyms	Comment	Organism
enoyl-ACP reductase	-	Plasmodium falciparum
ENR	-	Plasmodium falciparum
FabI	-	Plasmodium falciparum
pfENR	-	Plasmodium falciparum

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.5	-	activity assay	Plasmodium falciparum

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	-	Plasmodium falciparum

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0000106	-	epigallocatechin gallate	epigallocatechin gallate with triclosan	Plasmodium falciparum
0.000084	-	epigallocatechin gallate	-	Plasmodium falciparum

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Release 2023.1 (January 2023)