Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli Top10 cells | Staphylococcus aureus |
expressed in Escherichia coli Top10 cells | Escherichia coli |
Protein Variants | Comment | Organism |
---|---|---|
A95V aureus | triclosan-resistant mutant | Staphylococcus aureus |
A95V aureus | triclosan-resistant mutant | Escherichia coli |
G93V coli | triclosan-resistant mutant | Escherichia coli |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-(3-chlorobenzyl)-3-(2,6-dichlorobenzyl)-2-methylpyridin-4(1H)-one | - |
Escherichia coli | |
1-(3-chlorobenzyl)-3-(2,6-dichlorobenzyl)-2-methylpyridin-4(1H)-one | - |
Staphylococcus aureus | |
3-(2,6-dichlorobenzyl)-2-methyl-1-(2-methyl-2-[[3-(trifluoromethyl)benzyl]sulfanyl]propyl)pyridin-4(1H)-one | - |
Escherichia coli | |
3-(2,6-dichlorobenzyl)-2-methyl-1-(thiophen-2-ylmethyl)pyridin-4(1H)-one | - |
Escherichia coli | |
3-(2,6-dichlorobenzyl)-2-methyl-1-(thiophen-2-ylmethyl)pyridin-4(1H)-one | - |
Staphylococcus aureus | |
triclosan | - |
Escherichia coli | |
triclosan | - |
Staphylococcus aureus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Staphylococcus aureus | - |
strain ATCC 29213 | - |
Purification (Comment) | Organism |
---|---|
Ni-NTA agarose column chromatography | Staphylococcus aureus |
Ni-NTA agarose column chromatography | Escherichia coli |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
crotonyl-CoA + NADH + H+ | - |
Staphylococcus aureus | butyryl-CoA + NAD+ | - |
? | |
crotonyl-CoA + NADH + H+ | - |
Escherichia coli | butyryl-CoA + NAD+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
enoyl-acyl carrier protein reductase | - |
Staphylococcus aureus |
enoyl-acyl carrier protein reductase | - |
Escherichia coli |
FabI | - |
Staphylococcus aureus |
FabI | - |
Escherichia coli |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | - |
Staphylococcus aureus | |
NADH | - |
Escherichia coli |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00034 | - |
in 0.1 M sodium N-(2-acetamido)-iminodiacetic acid (pH 6.5) | Staphylococcus aureus | 1-(3-chlorobenzyl)-3-(2,6-dichlorobenzyl)-2-methylpyridin-4(1H)-one | |
0.00034 | - |
wild type enzyme, in 0.1 M sodium N-(2-acetamido)-iminodiacetic acid (pH 6.5) | Escherichia coli | 1-(3-chlorobenzyl)-3-(2,6-dichlorobenzyl)-2-methylpyridin-4(1H)-one | |
0.00035 | - |
in 0.1 M sodium N-(2-acetamido)-iminodiacetic acid (pH 6.5) | Staphylococcus aureus | 3-(2,6-dichlorobenzyl)-2-methyl-1-(thiophen-2-ylmethyl)pyridin-4(1H)-one | |
0.0004 | - |
wild type enzyme, in 0.1 M sodium N-(2-acetamido)-iminodiacetic acid (pH 6.5) | Escherichia coli | 3-(2,6-dichlorobenzyl)-2-methyl-1-(thiophen-2-ylmethyl)pyridin-4(1H)-one | |
0.00051 | - |
wild type enzyme, in 0.1 M sodium N-(2-acetamido)-iminodiacetic acid (pH 6.5) | Escherichia coli | triclosan | |
0.0018 | - |
wild type enzyme, in 0.1 M sodium N-(2-acetamido)-iminodiacetic acid (pH 6.5) | Escherichia coli | 3-(2,6-dichlorobenzyl)-2-methyl-1-(2-methyl-2-[[3-(trifluoromethyl)benzyl]sulfanyl]propyl)pyridin-4(1H)-one | |
0.0033 | - |
mutant enzyme G93V, in 0.1 M sodium N-(2-acetamido)-iminodiacetic acid (pH 6.5) | Escherichia coli | 1-(3-chlorobenzyl)-3-(2,6-dichlorobenzyl)-2-methylpyridin-4(1H)-one | |
0.0038 | - |
in 0.1 M sodium N-(2-acetamido)-iminodiacetic acid (pH 6.5) | Staphylococcus aureus | triclosan | |
0.0099 | - |
mutant enzyme G93V, in 0.1 M sodium N-(2-acetamido)-iminodiacetic acid (pH 6.5) | Escherichia coli | triclosan | |
0.038 | - |
mutant enzyme G93V, in 0.1 M sodium N-(2-acetamido)-iminodiacetic acid (pH 6.5) | Escherichia coli | 3-(2,6-dichlorobenzyl)-2-methyl-1-(thiophen-2-ylmethyl)pyridin-4(1H)-one |