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Literature summary for 1.3.1.9 extracted from

  • Oliveira, J.S.; Pereira, J.H.; Canduri, F.; Rodrigues, N.C.; de Souza, O.N.; de Azevedo, W.F.; Basso, L.A.; Santos, D.S.
    Crystallographic and pre-steady-state kinetics studies on binding of NADH to wild-type and isoniazid-resistant enoyl-ACP(CoA) reductase enzymes from Mycobacterium tuberculosis (2006), J. Mol. Biol., 359, 646-666.
    View publication on PubMed

Application

Application Comment Organism
medicine tuberculosis, TB, target of anti-tubercular agents Mycobacterium tuberculosis

Cloned(Commentary)

Cloned (Comment) Organism
-
Mycobacterium tuberculosis

Crystallization (Commentary)

Crystallization (Comment) Organism
wild-type enzyme, S94A, I47T and I21V mutants in complex with NADH at resolutions of 2.3 A, 2.2 A, 2.0 A, 1.9 A, respectively Mycobacterium tuberculosis

Protein Variants

Protein Variants Comment Organism
I21V mutant, studied for understanding of the isoniazid drug resistance mechanism Mycobacterium tuberculosis
I47T mutant, studied for understanding of the isoniazid drug resistance mechanism Mycobacterium tuberculosis
S94A mutant, studied for understanding of the isoniazid drug resistance mechanism Mycobacterium tuberculosis

Inhibitors

Inhibitors Comment Organism Structure
isoniazid
-
Mycobacterium tuberculosis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
104900
-
mutant I21V, estimated by gel-filtration chromatography Mycobacterium tuberculosis
108700
-
mutant S94A, estimated by gel-filtration chromatography Mycobacterium tuberculosis
115900
-
wild-type enzyme, estimated by gel-filtration chromatography Mycobacterium tuberculosis
118100
-
mutant I47T, estimated by gel-filtration chromatography Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acyl-[acyl-carrier protein] + NAD+ Mycobacterium tuberculosis
-
trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+
-
?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Mycobacterium tuberculosis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyl-[acyl-carrier protein] + NAD+
-
Mycobacterium tuberculosis trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+
-
?

Subunits

Subunits Comment Organism
homotetramer
-
Mycobacterium tuberculosis

Synonyms

Synonyms Comment Organism
2-trans enoyl-acyl carrier protein reductase
-
Mycobacterium tuberculosis
enoyl-ACP(CoA) reductase
-
Mycobacterium tuberculosis
enoyl-[acyl-carrier-protein] reductase
-
Mycobacterium tuberculosis
InhA
-
Mycobacterium tuberculosis

Cofactor

Cofactor Comment Organism Structure
NADH
-
Mycobacterium tuberculosis