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Literature summary for 1.3.1.9 extracted from

  • Kapoor, M.; Mukhi, P.L.; Surolia, N.; Suguna, K.; Surolia, A.
    Kinetic and structural analysis of the increased affinity of enoyl-ACP (acyl-carrier protein) reductase for triclosan in the presence of NAD+ (2004), Biochem. J., 381, 725-733.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Plasmodium falciparum

Crystallization (Commentary)

Crystallization (Comment) Organism
as binary complex with NADH and as ternary complex with NAD+ and triclosan, crystals diffract to 2.5 A and 2.2 A, respectively Plasmodium falciparum

Inhibitors

Inhibitors Comment Organism Structure
triclosan increase in inhibition in the presence of NAD+ due to the movement of the substrate-binding loop Plasmodium falciparum

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant PfENR Plasmodium falciparum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
trans-but-2-enoyl-CoA + NADH
-
Plasmodium falciparum butanoyl-CoA + NAD+
-
?

Synonyms

Synonyms Comment Organism
pfENR
-
Plasmodium falciparum

Cofactor

Cofactor Comment Organism Structure
NADH
-
Plasmodium falciparum