Literature summary for 1.3.1.86 extracted from

Stassi, D.L.; Kakavas, S.J.; Reynolds, K.A.; Gunawardana, G.; Swanson, S.; Zeidner, D.; Jackson, M.; Liu, H.; Buko, A.; Katz, L.
Ethyl-substituted erythromycin derivatives produced by directed metabolic engineering (1998), Proc. Natl. Acad. Sci. USA, 95, 7305-7309.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Streptomyces erythraea strain EAT4	Streptomyces collinus

Organism

Organism	UniProt	Comment	Textmining
Streptomyces collinus	-	-	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
0.0008	-	native enzyme, pH and temperature not specified in the publication	Streptomyces collinus
0.0156	-	recombinant enzyme, pH and temperature not specified in the publication	Streptomyces collinus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
crotonyl-CoA + NADPH + H+	-	Streptomyces collinus	butyryl-CoA + NADP+	-	?

Synonyms

Synonyms	Comment	Organism
CCR	-	Streptomyces collinus

Cofactor

Cofactor	Comment	Organism	Structure
NADPH	-	Streptomyces collinus

General Information

General Information	Comment	Organism
physiological function	in streptomycetes, Ccr catalyzes the last step in the reductive biosynthesis of butyryl-CoA from two molecules of acetyl-CoA	Streptomyces collinus

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Release 2023.1 (January 2023)