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Literature summary for 1.3.1.85 extracted from

  • Escudero, L.; Al-Refai, M.; Nieto, C.; Laatsch, H.; Malpartida, F.; Seco, E.M.
    New rimocidin/CE-108 derivatives obtained by a crotonyl-CoA carboxylase/reductase gene disruption in Streptomyces diastaticus var. 108: substrates for the polyene carboxamide synthase PcsA (2015), PLoS ONE, 10, e0135891.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli JM101 cells Streptomyces diastaticus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
crotonyl-CoA + CO2 + NADPH + H+ Streptomyces diastaticus
-
(2S)-ethylmalonyl-CoA + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Streptomyces diastaticus Q6T2B7 variant 108
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
crotonyl-CoA + CO2 + NADPH + H+
-
Streptomyces diastaticus (2S)-ethylmalonyl-CoA + NADP+
-
?

Synonyms

Synonyms Comment Organism
CCR
-
Streptomyces diastaticus
crotonyl-CoA carboxylase/reductase
-
Streptomyces diastaticus
rimJ
-
Streptomyces diastaticus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Streptomyces diastaticus