BRENDA - Enzyme Database show
show all sequences of 1.3.1.81

A systems biology approach identifies the biochemical mechanisms regulating monoterpenoid essential oil composition in peppermint

Rios-Estepa, R.; Turner, G.W.; Lee, J.M.; Croteau, R.B.; Lange, B.M.; Proc. Natl. Acad. Sci. USA 105, 2818-2823 (2008)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
(+)-menthofuran
weak competitive inhibition, in peppermint plants grown under low-light conditions, (+)-menthofuran is selectively retained in secretory cells and accumulated to very high levels of up to 20 mM, whereas under regular growth conditions, (+)-menthofuran levels remain very low, below 0.4 mM
Mentha x piperita
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
kinetic data analysis, overview
Mentha x piperita
0.04
-
(+)-pulegone
pH 6.6
Mentha x piperita
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2 (+)-pulegone + 2 NADPH + 2 H+
Mentha x piperita
branchpoint enzyme in essential oil biosynthesis
(-)-menthone + (+)-isomenthone + 2 NADP+
-
-
?
additional information
Mentha x piperita
kinetic modeling and simulations of the developmental patterns of monoterpenoid essential oil accumulation in peppermint, overview
?
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Mentha x piperita
-
cv. Black Mitcham
-
Purification (Commentary)
Commentary
Organism
native enzyme partially by isolation of secretory cells from leaves
Mentha x piperita
Source Tissue
Source Tissue
Commentary
Organism
Textmining
leaf
-
Mentha x piperita
-
secretory cell
-
Mentha x piperita
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2 (+)-pulegone + 2 NADPH + 2 H+
-
689800
Mentha x piperita
(-)-menthone + (+)-isomenthone + 2 NADP+
-
-
-
?
2 (+)-pulegone + 2 NADPH + 2 H+
branchpoint enzyme in essential oil biosynthesis
689800
Mentha x piperita
(-)-menthone + (+)-isomenthone + 2 NADP+
-
-
-
?
additional information
kinetic modeling and simulations of the developmental patterns of monoterpenoid essential oil accumulation in peppermint, overview
689800
Mentha x piperita
?
-
-
-
-
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
6.6
-
assay at
Mentha x piperita
Cofactor
Cofactor
Commentary
Organism
Structure
NADPH
-
Mentha x piperita
Ki Value [mM]
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.3
-
(+)-menthofuran
pH 6.6
Mentha x piperita
IC50 Value
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
0.15
-
pH 6.6
Mentha x piperita
(+)-menthofuran
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NADPH
-
Mentha x piperita
IC50 Value (protein specific)
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
0.15
-
pH 6.6
Mentha x piperita
(+)-menthofuran
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
(+)-menthofuran
weak competitive inhibition, in peppermint plants grown under low-light conditions, (+)-menthofuran is selectively retained in secretory cells and accumulated to very high levels of up to 20 mM, whereas under regular growth conditions, (+)-menthofuran levels remain very low, below 0.4 mM
Mentha x piperita
Ki Value [mM] (protein specific)
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.3
-
(+)-menthofuran
pH 6.6
Mentha x piperita
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
kinetic data analysis, overview
Mentha x piperita
0.04
-
(+)-pulegone
pH 6.6
Mentha x piperita
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2 (+)-pulegone + 2 NADPH + 2 H+
Mentha x piperita
branchpoint enzyme in essential oil biosynthesis
(-)-menthone + (+)-isomenthone + 2 NADP+
-
-
?
additional information
Mentha x piperita
kinetic modeling and simulations of the developmental patterns of monoterpenoid essential oil accumulation in peppermint, overview
?
-
-
-
Purification (Commentary) (protein specific)
Commentary
Organism
native enzyme partially by isolation of secretory cells from leaves
Mentha x piperita
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
leaf
-
Mentha x piperita
-
secretory cell
-
Mentha x piperita
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2 (+)-pulegone + 2 NADPH + 2 H+
-
689800
Mentha x piperita
(-)-menthone + (+)-isomenthone + 2 NADP+
-
-
-
?
2 (+)-pulegone + 2 NADPH + 2 H+
branchpoint enzyme in essential oil biosynthesis
689800
Mentha x piperita
(-)-menthone + (+)-isomenthone + 2 NADP+
-
-
-
?
additional information
kinetic modeling and simulations of the developmental patterns of monoterpenoid essential oil accumulation in peppermint, overview
689800
Mentha x piperita
?
-
-
-
-
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
6.6
-
assay at
Mentha x piperita
Other publictions for EC 1.3.1.81
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
746411
Li
MAPK-mediated regulation of g ...
Mentha x piperita
Protoplasma
253
1541-1556
2016
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1
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3
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2
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1
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1
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1
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1
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2
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1
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-
2
2
-
-
-
712853
Dolzhenko
UV-B modulates the interplay b ...
Mentha x piperita
J. Photochem. Photobiol. B Biol.
100
67-75
2010
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-
1
-
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1
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2
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1
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1
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2
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1
2
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1
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1
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1
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1
1
1
1
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713312
Rios-Estepa
Mathematical modeling-guided e ...
Mentha x piperita
Plant Physiol.
152
2105-2119
2010
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1
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1
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3
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2
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2
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2
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1
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3
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2
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2
2
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725777
Dolzhenko
UV-B modulates the interplay b ...
Mentha x piperita
J. Photochem. Photobiol. B
100
67-75
2010
-
-
-
-
-
-
1
-
-
-
-
-
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2
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1
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1
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1
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1
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1
-
-
689800
Rios-Estepa
A systems biology approach ide ...
Mentha x piperita
Proc. Natl. Acad. Sci. USA
105
2818-2823
2008
-
-
-
-
-
-
1
2
-
-
-
2
-
2
-
-
1
-
-
2
-
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3
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-
1
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1
1
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1
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1
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1
1
1
2
-
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2
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1
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2
-
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3
-
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1
-
-
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-
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670589
Ringer
Monoterpene metabolism. Clonin ...
Mentha spicata, Mentha x piperita
Plant Physiol.
137
863-872
2005
-
-
-
-
-
-
-
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2
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2
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4
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2
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2
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2
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4
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660251
Turner
Organization of monoterpene bi ...
Mentha x piperita
Plant Physiol.
136
4215-4227
2004
-
-
1
-
-
-
-
-
1
-
1
1
-
4
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1
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1
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2
1
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1
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1
1
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1
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1
1
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1
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1
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2
1
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-
-
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684664
Ringer
Monoterpene double-bond reduct ...
Mentha x piperita
Arch. Biochem. Biophys.
418
80-92
2003
-
-
1
-
-
1
-
2
-
-
3
1
-
3
-
-
1
-
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3
-
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2
1
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2
1
1
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1
-
1
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1
1
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1
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2
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3
1
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1
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3
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2
1
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2
1
1
-
1
-
-
-
-
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-
689735
Mahmoud
Menthofuran regulates essentia ...
Mentha x piperita
Proc. Natl. Acad. Sci. USA
100
14481-14486
2003
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1
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1
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2
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3
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1
1
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3
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1
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1
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1
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1
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2
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1
1
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3
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