BRENDA - Enzyme Database show
show all sequences of 1.3.1.81

Menthofuran regulates essential oil biosynthesis in peppermint by controlling a downstream monoterpene reductase

Mahmoud, S.S.; Croteau, R.B.; Proc. Natl. Acad. Sci. USA 100, 14481-14486 (2003)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
additional information
although (+)-menthofuran does not inhibit (+)-pulegone reductase activity, stem feeding with menthofuran selectively decreases enzyme transcript levels in immature leaves, thereby accounting for decreased reductase activity and increased pulegone content, overview, the flux of (+)-pulegone through pulegone reductase correlates negatively with the essential oil content of menthofuran, such that menthofuran, and pulegone increase, or decrease, in concert, overview
Mentha x piperita
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
soluble
-
Mentha x piperita
-
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2 (+)-pulegone + 2 NADPH + 2 H+
Mentha x piperita
regulation of pulegone metabolism involves menthofuran, the flux of (+)-pulegone through pulegone reductase correlates negatively with the essential oil content of menthofuran, such that menthofuran, and pulegone increase, or decrease, in concert, overview
(-)-menthone + (+)-isomenthone + 2 NADP+
-
-
?
additional information
Mentha x piperita
pathways for monoterpene biosynthesis in peppermint, overview
?
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Mentha x piperita
-
cv. Black Mitcham
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
leaf
-
Mentha x piperita
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
additional information
-
essential oil composition of wild-type peppermint
Mentha x piperita
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2 (+)-pulegone + 2 NADPH + 2 H+
-
689735
Mentha x piperita
(-)-menthone + (+)-isomenthone + 2 NADP+
-
-
-
?
2 (+)-pulegone + 2 NADPH + 2 H+
regulation of pulegone metabolism involves menthofuran, the flux of (+)-pulegone through pulegone reductase correlates negatively with the essential oil content of menthofuran, such that menthofuran, and pulegone increase, or decrease, in concert, overview
689735
Mentha x piperita
(-)-menthone + (+)-isomenthone + 2 NADP+
-
-
-
?
additional information
pathways for monoterpene biosynthesis in peppermint, overview
689735
Mentha x piperita
?
-
-
-
-
Cofactor
Cofactor
Commentary
Organism
Structure
NADPH
-
Mentha x piperita
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NADPH
-
Mentha x piperita
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
additional information
although (+)-menthofuran does not inhibit (+)-pulegone reductase activity, stem feeding with menthofuran selectively decreases enzyme transcript levels in immature leaves, thereby accounting for decreased reductase activity and increased pulegone content, overview, the flux of (+)-pulegone through pulegone reductase correlates negatively with the essential oil content of menthofuran, such that menthofuran, and pulegone increase, or decrease, in concert, overview
Mentha x piperita
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
soluble
-
Mentha x piperita
-
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2 (+)-pulegone + 2 NADPH + 2 H+
Mentha x piperita
regulation of pulegone metabolism involves menthofuran, the flux of (+)-pulegone through pulegone reductase correlates negatively with the essential oil content of menthofuran, such that menthofuran, and pulegone increase, or decrease, in concert, overview
(-)-menthone + (+)-isomenthone + 2 NADP+
-
-
?
additional information
Mentha x piperita
pathways for monoterpene biosynthesis in peppermint, overview
?
-
-
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
leaf
-
Mentha x piperita
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
additional information
-
essential oil composition of wild-type peppermint
Mentha x piperita
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2 (+)-pulegone + 2 NADPH + 2 H+
-
689735
Mentha x piperita
(-)-menthone + (+)-isomenthone + 2 NADP+
-
-
-
?
2 (+)-pulegone + 2 NADPH + 2 H+
regulation of pulegone metabolism involves menthofuran, the flux of (+)-pulegone through pulegone reductase correlates negatively with the essential oil content of menthofuran, such that menthofuran, and pulegone increase, or decrease, in concert, overview
689735
Mentha x piperita
(-)-menthone + (+)-isomenthone + 2 NADP+
-
-
-
?
additional information
pathways for monoterpene biosynthesis in peppermint, overview
689735
Mentha x piperita
?
-
-
-
-
Other publictions for EC 1.3.1.81
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
746411
Li
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Protoplasma
253
1541-1556
2016
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3
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1
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1
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2
2
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712853
Dolzhenko
UV-B modulates the interplay b ...
Mentha x piperita
J. Photochem. Photobiol. B Biol.
100
67-75
2010
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1
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1
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1
1
1
1
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713312
Rios-Estepa
Mathematical modeling-guided e ...
Mentha x piperita
Plant Physiol.
152
2105-2119
2010
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1
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1
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2
2
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725777
Dolzhenko
UV-B modulates the interplay b ...
Mentha x piperita
J. Photochem. Photobiol. B
100
67-75
2010
-
-
-
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-
1
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2
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1
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1
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1
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689800
Rios-Estepa
A systems biology approach ide ...
Mentha x piperita
Proc. Natl. Acad. Sci. USA
105
2818-2823
2008
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1
2
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2
-
2
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1
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2
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3
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1
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1
1
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1
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1
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1
1
1
2
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2
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1
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2
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3
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1
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670589
Ringer
Monoterpene metabolism. Clonin ...
Mentha spicata, Mentha x piperita
Plant Physiol.
137
863-872
2005
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2
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2
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4
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660251
Turner
Organization of monoterpene bi ...
Mentha x piperita
Plant Physiol.
136
4215-4227
2004
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1
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1
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1
1
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4
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1
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1
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2
1
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1
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1
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684664
Ringer
Monoterpene double-bond reduct ...
Mentha x piperita
Arch. Biochem. Biophys.
418
80-92
2003
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1
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1
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2
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3
1
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3
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1
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3
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1
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1
1
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1
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1
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1
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1
1
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1
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689735
Mahmoud
Menthofuran regulates essentia ...
Mentha x piperita
Proc. Natl. Acad. Sci. USA
100
14481-14486
2003
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