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Literature summary for 1.3.1.8 extracted from

  • Li, C.; Florova, G.; Akopiants, K.; Reynolds, K.A.
    Crotonyl-coenzyme A reductase provides methylmalonyl-CoA precursors for monensin biosynthesis by Streptomyces cinnamonensis in an oil-based extended fermentation (2004), Microbiology, 150, 3463-3472.
    View publication on PubMed
Search for more literature for 1.3.1.8

Application

Application Comment Organism
biotechnology optimization of oil-based extended fermentation of recombinant Streptomyces cinnamonensis, expressing the enzyme from Streptomyces collinus, is used to provide methylmalonyl-CoA precursors for monensin biosynthesis, overview Streptomyces collinus
synthesis oil-based extended fermentation of recombinant Streptomyces cinnamonensis, expressing the enzyme from Streptomyces collinus, is used to provide methylmalonyl-CoA precursors for monensin biosynthesis Streptomyces collinus

Cloned(Commentary)

Cloned (Comment) Organism
expression in Streptomyces cinnamonensis strains C730.1 and L1 Streptomyces collinus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
crotonyl-CoA + reduced acceptor Streptomyces collinus enzyme is involved in synthesizing methylmalonyl-CoA precursors for monensin biosynthesis, pathway flux, overview butyryl-CoA + oxidized acceptor
-
 ?

Organism

Organism UniProt Comment Textmining
Streptomyces collinus
-
 gene ccr, enzyme CCR
-

Reaction

Reaction Comment Organism Reaction ID
acyl-CoA + NADP+ = 2,3-dehydroacyl-CoA + NADPH + H+ enzyme might also belong to EC 1.3.99.3, acyl-CoA dehydrogenase Streptomyces collinus
a

Source Tissue

Source Tissue Comment Organism Textmining
additional information fermentation in an oil-based medium Streptomyces collinus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 quantification by determination of monensin A Streptomyces collinus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
crotonyl-CoA + reduced acceptor
-
 Streptomyces collinus butyryl-CoA + oxidized acceptor
-
 ?
crotonyl-CoA + reduced acceptor enzyme is involved in synthesizing methylmalonyl-CoA precursors for monensin biosynthesis, pathway flux, overview Streptomyces collinus butyryl-CoA + oxidized acceptor
-
 ?

Synonyms

Synonyms Comment Organism
CCR ambiguous Streptomyces collinus
crotonyl-coenzyme A reductase
-
 Streptomyces collinus