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Literature summary for 1.3.1.8 extracted from

  • Seubert, W.; Lamberts, I.; Kramer, R.; Ohly, B.
    On the mechanism of malonyl-CoA-independent fatty acid synthesis. I. The mechanism of elongation of long-chain fatty acids by acetyl-CoA (1968), Biochim. Biophys. Acta, 164, 498-517.
    View publication on PubMed
Search for more literature for 1.3.1.8

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus specific for alpha/beta-unsaturated CoA derivatives with chain lengths of 4-16 C atoms, neither involved in beta-oxidation of fatty acids nor de novo-synthesis of fatty acids via malonyl-CoA ?
-
 ?
additional information Rattus norvegicus involvement in malonyl-CoA fatty acid elongation system II ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 no information in the literature concerning reduction of cis-2-enoyl-CoA substrates, thus classification of rat enzyme according to EC 1.3.1.8 or EC 1.3.1.38 impossible
-

Purification (Commentary)

Purification (Comment) Organism
partial Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.04
-
-
 Rattus norvegicus

Storage Stability

Storage Stability Organism
-15°C, sucrose solution, loss of 15-20% activity overnight Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-cis-octenoyl-CoA + NADPH substrate is not specified as cis- or trans-octenoyl-CoA Rattus norvegicus octanoyl-CoA + NADP+
-
 ?
2-trans-octenoyl-CoA + NAD(P)H substrate is not specified as cis- or trans-octenoyl-CoA Rattus norvegicus octanoyl-CoA + NADP+
-
 ?
additional information specific for alpha/beta-unsaturated CoA derivatives with chain lengths of 4-16 C atoms, neither involved in beta-oxidation of fatty acids nor de novo-synthesis of fatty acids via malonyl-CoA Rattus norvegicus ?
-
 ?
additional information involvement in malonyl-CoA fatty acid elongation system II Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
enoyl-CoA reductase
-
 Rattus norvegicus
NADPH:enoyl-CoA oxidoreductase
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADPH inactive with NADH Rattus norvegicus