Data extracted from this reference:
Inhibitors
Isonicotinamide
Mycolicibacterium smegmatis
monoiodoacetate
Mycolicibacterium smegmatis
N-ethylmaleimide
Mycolicibacterium smegmatis
KM Value [mM]
0.083
(2E)-eicosenoyl-CoA
Mycolicibacterium smegmatis
0.1
2-trans-hexadecenoyl-CoA
Mycolicibacterium smegmatis
Molecular Weight [Da]
30000
60000
gel filtration
Mycolicibacterium smegmatis
32000
? * 32000, SDS-PAGE, monomer or dimer
Mycolicibacterium smegmatis
Natural Substrates/ Products (Substrates)
additional information
Mycolicibacterium smegmatis
involvement in malonyl-CoA fatty acid elongation system II
?
Organism
Mycolicibacterium smegmatis
Purification (Commentary)
Mycolicibacterium smegmatis
Specific Activity [micromol/min/mg]
1.25
Mycolicibacterium smegmatis
Substrates and Products (Substrate)
2-trans-hexadecenoyl-CoA + NADPH
390849
Mycolicibacterium smegmatis
hexadecanoyl CoA + NADP+
?
crotonyl-CoA + NAD(P)H
390849
Mycolicibacterium smegmatis
butanoyl-CoA + NADP+
?
additional information
very slow reduction of substrate with chain length C4, C10, C12
390849
Mycolicibacterium smegmatis
?
additional information
FMN is essential for the reaction, tightly bound to apoprotein
390849
Mycolicibacterium smegmatis
?
additional information
involvement in malonyl-CoA fatty acid elongation system II
390849
Mycolicibacterium smegmatis
?
trans-2-eicosenoyl-CoA + NADPH
390849
Mycolicibacterium smegmatis
eicosanoyl-CoA + NADP+
i.e. arachidoyl-CoA
390849
Mycolicibacterium smegmatis
?
Subunits
?
? * 32000, SDS-PAGE, monomer or dimer
Mycolicibacterium smegmatis
Temperature Optimum [°C]
37
assay at
Mycolicibacterium smegmatis
pH Optimum
6
6.5
Mycolicibacterium smegmatis
7
assay at
Mycolicibacterium smegmatis
Cofactor
FMN
1 mol per mol of protein, prosthetic group is essentiell for the reaction
Mycolicibacterium smegmatis
NADPH
inactive with NADH
Mycolicibacterium smegmatis
Cofactor (protein specific)
FMN
1 mol per mol of protein, prosthetic group is essentiell for the reaction
Mycolicibacterium smegmatis
NADPH
inactive with NADH
Mycolicibacterium smegmatis
Inhibitors (protein specific)
Isonicotinamide
Mycolicibacterium smegmatis
monoiodoacetate
Mycolicibacterium smegmatis
N-ethylmaleimide
Mycolicibacterium smegmatis
KM Value [mM] (protein specific)
0.083
(2E)-eicosenoyl-CoA
Mycolicibacterium smegmatis
0.1
2-trans-hexadecenoyl-CoA
Mycolicibacterium smegmatis
Molecular Weight [Da] (protein specific)
30000
60000
gel filtration
Mycolicibacterium smegmatis
32000
? * 32000, SDS-PAGE, monomer or dimer
Mycolicibacterium smegmatis
Natural Substrates/ Products (Substrates) (protein specific)
additional information
Mycolicibacterium smegmatis
involvement in malonyl-CoA fatty acid elongation system II
?
Purification (Commentary) (protein specific)
Mycolicibacterium smegmatis
Specific Activity [micromol/min/mg] (protein specific)
1.25
Mycolicibacterium smegmatis
Substrates and Products (Substrate) (protein specific)
2-trans-hexadecenoyl-CoA + NADPH
390849
Mycolicibacterium smegmatis
hexadecanoyl CoA + NADP+
?
crotonyl-CoA + NAD(P)H
390849
Mycolicibacterium smegmatis
butanoyl-CoA + NADP+
?
additional information
very slow reduction of substrate with chain length C4, C10, C12
390849
Mycolicibacterium smegmatis
?
additional information
FMN is essential for the reaction, tightly bound to apoprotein
390849
Mycolicibacterium smegmatis
?
additional information
involvement in malonyl-CoA fatty acid elongation system II
390849
Mycolicibacterium smegmatis
?
trans-2-eicosenoyl-CoA + NADPH
390849
Mycolicibacterium smegmatis
eicosanoyl-CoA + NADP+
i.e. arachidoyl-CoA
390849
Mycolicibacterium smegmatis
?
Subunits (protein specific)
?
? * 32000, SDS-PAGE, monomer or dimer
Mycolicibacterium smegmatis
Temperature Optimum [°C] (protein specific)
37
assay at
Mycolicibacterium smegmatis
pH Optimum (protein specific)
6
6.5
Mycolicibacterium smegmatis
7
assay at
Mycolicibacterium smegmatis
Other publictions for EC
712769
Sugishima
Crystal structures of the subs ...
Arabidopsis thaliana
J. Mol. Biol.
402
879-891
2010
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685980
Rennison
Enhanced acyl-CoA dehydrogenas ...
Rattus norvegicus
Cardiovasc. Res.
79
331-340
2008
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689745
Erb
Synthesis of C5-dicarboxylic a ...
Rhodobacter sphaeroides
Proc. Natl. Acad. Sci. USA
104
10631-10636
2007
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1
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673619
Park
Silencing of NbECR encoding a ...
Nicotiana benthamiana
FEBS Lett.
579
4459-4464
2005
-
-
-
-
-
-
-
-
2
-
1
1
-
2
-
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-
-
-
6
-
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1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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2
-
1
1
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-
6
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
656737
Li
Crotonyl-coenzyme A reductase ...
Streptomyces collinus
Microbiology
150
3463-3472
2004
-
2
1
-
-
-
-
-
-
-
-
1
-
3
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1
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1
1
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2
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2
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2
1
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1
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-
1
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
390872
Sargueil
High metabolism and subsequent ...
Mus musculus
Neurosci. Lett.
273
29-32
1999
-
-
-
-
-
-
-
-
1
-
-
2
-
2
-
-
-
-
-
1
4
-
3
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
1
4
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
390873
Lessire
Study of the 3-hydroxy-eicosan ...
Allium ampeloprasum
Plant Physiol.
119
1009-1015
1999
-
-
-
-
-
-
-
-
1
-
-
1
-
3
-
-
-
-
-
1
1
-
2
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
390869
Mukherjee
Inactivation of enoyl-CoA redu ...
Columba sp.
J. Enzyme Inhib.
13
217-228
1998
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
390868
Mukherjee
Evidence for the essential his ...
Columba sp.
J. Enzyme Inhib.
11
209-216
1997
-
-
-
-
-
-
1
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
390759
Laguna
Action of Ebselen on rat hepat ...
Rattus norvegicus
Arch. Biochem. Biophys.
269
272-283
1989
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
390758
Nagi
Dual action of 2-decynoyl coen ...
Rattus norvegicus
Arch. Biochem. Biophys.
267
1-12
1988
-
-
-
-
-
-
1
-
1
-
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-
-
1
-
-
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-
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1
-
-
2
-
-
-
-
-
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1
-
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-
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-
1
-
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-
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1
-
-
1
-
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-
-
-
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-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
390757
Nagi
Site of inhibition of rat live ...
Rattus norvegicus
J. Biol. Chem.
261
13598-13605
1986
-
-
-
-
-
-
1
-
1
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
390753
Prasad
Solubilization and purificatio ...
Rattus norvegicus
Arch. Biochem. Biophys.
237
535-544
1985
-
-
-
-
-
-
1
4
1
-
-
-
-
2
-
-
1
-
-
1
1
-
8
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
4
1
-
-
-
-
-
-
1
-
1
1
-
8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
390870
Cvetanovic
Purification and characterizat ...
Bos taurus
Biochem. J.
227
49-56
1985
-
-
-
-
-
-
5
-
2
-
4
-
-
2
-
-
1
-
-
2
5
-
8
1
1
1
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
5
-
-
2
-
4
-
-
-
-
1
-
2
5
-
8
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
390810
Inui
Fatty acid synthesis in mitoch ...
Euglena gracilis
Eur. J. Biochem.
142
121-126
1984
-
-
-
-
-
-
-
-
3
-
-
1
-
4
-
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-
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-
-
-
9
-
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-
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-
2
-
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-
2
-
-
-
-
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-
3
-
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1
-
-
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-
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-
9
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
390849
Kikuchi
Purification of NADPH-dependen ...
Mycolicibacterium smegmatis
J. Biochem.
96
841-848
1984
-
-
-
-
-
-
3
2
-
-
2
1
-
4
-
-
1
-
-
-
1
-
6
1
-
1
-
-
-
2
-
-
2
-
-
-
-
-
-
2
-
-
-
-
3
-
2
-
-
2
1
-
-
-
1
-
-
1
-
6
1
1
-
-
-
2
-
-
-
-
-
-
-
-
-
390754
Nagi
Biochemical properties of shor ...
Rattus norvegicus
Arch. Biochem. Biophys.
226
50-64
1983
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
1
-
-
3
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
390755
Prasad
Kinetic evidence for two separ ...
Rattus norvegicus
Biochem. Biophys. Res. Commun.
113
659-665
1983
-
-
-
-
-
-
-
-
1
-
-
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-
1
-
-
-
-
-
1
-
-
5
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
390756
Cinti
Evidence for a second microsom ...
Rattus norvegicus
J. Biol. Chem.
257
14333-14340
1982
-
-
-
-
-
-
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1
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1
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1
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3
-
1
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1
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1
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1
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1
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3
-
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-
-
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-
-
-
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-
-
-
-
-
390752
Bernert
The isolation of acyl-CoA deri ...
Rattus norvegicus
Biochim. Biophys. Acta
573
436-442
1979
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
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-
1
-
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1
-
1
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-
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-
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1
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1
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1
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-
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-
1
-
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1
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
390850
Strom
-
Activation and inhibition of c ...
Bos taurus
J. Biol. Chem.
254
8159-8162
1979
1
-
-
-
-
-
9
-
-
-
-
-
-
1
-
-
-
-
-
1
-
1
1
-
-
-
-
-
-
1
1
-
1
4
-
-
1
-
-
1
-
-
-
-
9
4
-
-
-
-
-
-
-
-
-
-
1
-
1
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
390851
Strom
Enoyl coenzyme A reduction by ...
Bos taurus
J. Biol. Chem.
254
8153-8158
1979
-
-
-
-
-
1
2
-
-
-
-
-
-
2
1
-
1
-
-
1
1
1
8
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
1
-
2
-
-
-
-
-
-
-
1
-
1
-
1
1
1
8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
390751
Bernert
An analysis of partial reactio ...
Rattus norvegicus
J. Biol. Chem.
252
6736-6744
1977
1
-
-
-
-
-
2
-
1
-
-
-
-
1
-
-
-
-
-
1
-
-
6
-
1
-
-
-
-
1
-
-
1
-
-
-
1
-
-
1
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
1
-
-
6
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
390852
Maitra
Crotonyl coenzyme A reductase ...
Bos taurus
J. Biol. Chem.
249
111-117
1974
1
-
-
-
-
-
1
3
-
-
-
-
-
2
-
-
1
-
-
1
-
-
1
-
-
1
1
-
-
1
-
-
2
-
-
-
1
-
-
2
-
-
-
-
1
-
3
-
-
-
-
-
-
-
1
-
1
-
-
1
-
1
1
-
-
1
-
-
-
-
-
-
-
-
-
390853
Ishidate
Induction of NADPH enoyl-coA r ...
Candida albicans
J. Biochem.
76
1139-1142
1974
-
-
-
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390854
Ishidate
Separation and some characteri ...
Candida albicans
Chem. Pharm. Bull.
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2685-2691
1974
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6
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390855
Mizugaki
Stereospecific hydrogen transf ...
Rattus norvegicus
J. Biochem.
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691-696
1973
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390856
Mizugaki
Possible role of NADPH-depende ...
Rattus norvegicus
Biochem. Biophys. Res. Commun.
50
48-53
1973
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3
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390857
Podack
On the mechanism of malonyl-Co ...
Rattus norvegicus
Biochim. Biophys. Acta
280
235-247
1972
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390858
Seubert
On the mechanism of malonyl-Co ...
Rattus norvegicus
Biochim. Biophys. Acta
164
498-517
1968
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