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Literature summary for 1.3.1.8 extracted from

  • Inui, H.; Miyatake, K.; Nakano, Y.; Kitaoka, S.
    Fatty acid synthesis in mitochondria of Euglena gracilis (1984), Eur. J. Biochem., 142, 121-126.
    View publication on PubMed
Search for more literature for 1.3.1.8

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
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 Euglena gracilis 5829
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microsome
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 Euglena gracilis
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mitochondrion soluble fraction of mitochondria Euglena gracilis 5739
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Euglena gracilis active as part of fatty acid synthetase by incorporation of acetyl-CoA in mitochondria and of malonyl-CoA in cytosol ?
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 ?

Organism

Organism UniProt Comment Textmining
Euglena gracilis
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 3 different enzyme isoforms I, II and III, not exactly differentiated concerning elongation system I and II
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-trans-decenoyl-CoA + NAD(P)H mitochondrial reductase II shows high activity, cofactor NADH Euglena gracilis decanoyl-CoA + NADP+
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 ?
2-trans-dodecenoyl-CoA + NAD(P)H mitochondrial reductases II and III, low activity, cofactor NADH for isoform II and NADH or NADPH for isoform III Euglena gracilis dodecanoyl-CoA + NAD(P)+
-
 ?
2-trans-hexenoyl-CoA + NAD(P)H mitochondrial enzymes, reductase III shows highest activity, reductase I shows 45% activity of that with crotonyl-CoA, reductase II shows lower activity, cofactor NADH for isoform I and II and NADH or NADPH for isoform III Euglena gracilis hexanoyl-CoA + NADP+
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 ?
2-trans-octadecenoyl-CoA + NAD(P)H cofactor NADH, mitochondrial reductase I shows 25% activity of that with crotonyl-CoA, reductase II shows highest activity Euglena gracilis octadecanoyl-CoA + NAD(P)+
-
 ?
2-trans-octenoyl-CoA + NAD(P)H mitochondrial enzyme, NADH-specific reaction Euglena gracilis octanoyl-CoA + NADP+
-
 ?
crotonyl-CoA + NAD(P)H mitochondrial reductase I, no specification of stereoisomer, cofactor NADH Euglena gracilis butanoyl-CoA + NADP+
-
 ?
additional information mitochondrial reductase III uses substrate with chain length of C4-C12 Euglena gracilis ?
-
 ?
additional information no cis-isomeric substrates tested, classification is not definite Euglena gracilis ?
-
 ?
additional information active as part of fatty acid synthetase by incorporation of acetyl-CoA in mitochondria and of malonyl-CoA in cytosol Euglena gracilis ?
-
 ?

Cofactor

Cofactor Comment Organism Structure
NADH reductases I and II Euglena gracilis
NADPH reductase III Euglena gracilis