Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | bovine serum albumin in assay mixture elevated the activity | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-trans-octadecenoyl-CoA | without bovine serum albumin substrate-induced inhibition at 0.02-0.03 mM | Rattus norvegicus | |
palmitoyl-CoA | without bovine serum albumin substrate-induced inhibition at 0.02-0.03 mM | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Rattus norvegicus | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
no information in the literature concerning reduction of cis-2-enoyl-CoA substrates, thus classification of rat enzyme according to EC 1.3.1.8 or EC 1.3.1.38 impossible | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-trans-8,11-eicosatrienoyl-CoA + NADPH | fat-free dietary elevates the activity | Rattus norvegicus | 8,11-eicosadienoyl-CoA + NADP+ | - |
? | |
2-trans-hexadecenoyl-CoA + NADPH | - |
Rattus norvegicus | hexadecanoyl CoA + NADP+ | - |
? | |
2-trans-octadecenoyl-CoA + NAD(P)H | i.e. 2-trans-oleoyl-CoA | Rattus norvegicus | octadecanoyl-CoA + NAD(P)+ | - |
? | |
2-trans-octenoyl-CoA + NAD(P)H | - |
Rattus norvegicus | octanoyl-CoA + NADP+ | - |
? | |
6,9-octadecadienoyl-CoA + NADPH | fat-free dietary elevates the activity | Rattus norvegicus | ? | - |
? | |
additional information | NADPH specific trans-enoyl-CoA reductases isolated from rat liver microsomes and mitochondria impossible to classify according to EC 1.3.1.8 or EC 1.3.1.38 because no cis-isomers of 2-enoyl-CoA have been tested as substrates | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
2-trans-enoyl-CoA reductase | - |
Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.3 | - |
in HEPES and Bicine buffer | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | inactive with NADH | Rattus norvegicus |