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Literature summary for 1.3.1.72 extracted from

  • Koerner, A.; Zhou, E.; Mueller, C.; Mohammed, Y.; Herceg, S.; Bracher, F.; Rensen, P.C.N.; Wang, Y.; Mirakaj, V.; Giera, M.
    Inhibition of DELTA24-dehydrocholesterol reductase activates pro-resolving lipid mediator biosynthesis and inflammation resolution (2019), Proc. Natl. Acad. Sci. USA, 116, 20623-20634 .
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
SH42 potent inhibitor Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
desmosterol + NADPH + H+ Mus musculus
-
 cholesterol + NADP+
-
 ?
lanosterol + NADPH + H+ Mus musculus
-
 dihydrolanosterol + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
peritoneal cell line
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
desmosterol + NADPH + H+
-
 Mus musculus cholesterol + NADP+
-
 ?
lanosterol + NADPH + H+
-
 Mus musculus dihydrolanosterol + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
DELTA24-dehydrocholesterol reductase
-
 Mus musculus
DHCR24
-
 Mus musculus
seladin-1
-
 Mus musculus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000005
-
 pH and temperature not specified in the publication Mus musculus SH42

General Information

General Information Comment Organism
malfunction enzyme inhibition leads to increased inflammation resolution and selectively decreases proinflammatory cell influx Mus musculus