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Literature summary for 1.3.1.72 extracted from

  • Yavuz, U.; Alaylioglu, M.; Senguel, B.; Karras, S.N.; Gezen-Ak, D.; Dursun, E.
    Protein disulfide isomerase A3 might be involved in the regulation of 24-dehydrocholesterol reductase via vitamin D equilibrium in primary cortical neurons (2021), In Vitro Cell. Dev. Biol. Anim., 57, 704-714 .
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
desmosterol + NADPH + H+ Rattus norvegicus
-
 cholesterol + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryo
-
 Rattus norvegicus
-
primary cortical neuron
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
desmosterol + NADPH + H+
-
 Rattus norvegicus cholesterol + NADP+
-
 ?

Subunits

Subunits Comment Organism
? x * 54000, SDS-PAGE Rattus norvegicus

Synonyms

Synonyms Comment Organism
24-dehydrocholesterol reductase
-
 Rattus norvegicus
DHCR24
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus the mRNA expression of the enzyme is significantly decreased in the cortical neurons treated with 0.00001 mM 1,25-dihydroxyvitamin D3 down
Rattus norvegicus enzyme mRNA expression level is significantly increased in protein disulfide isomerase A3 siRNA-treated neurons up