Literature summary for 1.3.1.72 extracted from

Fujimori, H.; Zhou, Y.; Fukumura, K.; Matsumoto, S.; Tukamoto, Y.; Nagata, S.
Specific distribution of expression and enzymatic activity of cholesterol biosynthetic enzyme DHCR24 orthologs in the phytophagous insect (2020), Biosci. Biotechnol. Biochem., 84, 126-133 .

Search for more literature for 1.3.1.72

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in HEK-293 cells	Bombyx mori

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
endoplasmic reticulum	-	Bombyx mori	5783	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
desmosterol + NADPH + H+	Bombyx mori	-	cholesterol + NADP+	-	?

Organism

Organism	UniProt	Comment	Textmining
Bombyx mori	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
larva	-	Bombyx mori	-
midgut	predominant enzymatic activity in the larval midgut	Bombyx mori	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
desmosterol + NADPH + H+	-	Bombyx mori	cholesterol + NADP+	-	?

Synonyms

Synonyms	Comment	Organism
24-dehydrocholesterol reductase	-	Bombyx mori
DHCR24-1	isoform	Bombyx mori
DHCR24-2	isoform	Bombyx mori

Cofactor

Cofactor	Comment	Organism	Structure
FAD	-	Bombyx mori
NADPH	-	Bombyx mori

General Information

General Information	Comment	Organism
metabolism	isoform DHCR24-1 but not DHCR24-2 contributes to conversion of phytosterols to cholesterol mainly in the midgut of Bombyx mori larvae	Bombyx mori

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Release 2023.1 (January 2023)