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Literature summary for 1.3.1.72 extracted from

  • Tabrez, S.; Rahman, F.; Ali, R.; Akand, S.K.; Alaidarous, M.A.; Banawas, S.; Dukhyil, A.A.B.; Rub, A.
    Hesperidin targets Leishmania donovani sterol C-24 reductase to fight against leishmaniasis (2021), ACS Omega, 6, 8112-8118 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.3.1.72

Inhibitors

Inhibitors Comment Organism Structure
hesperidin
-
 Leishmania donovani

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH + H+ Leishmania donovani
-
 ergosterol + NADP+
-
 ?
ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH + H+ Leishmania donovani BPK282A1
-
 ergosterol + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Leishmania donovani E9BQ02
-
-
Leishmania donovani BPK282A1 E9BQ02
-
-

Source Tissue

Source Tissue Comment Organism Textmining
amastigote
-
 Leishmania donovani
-
promastigote
-
 Leishmania donovani
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH + H+
-
 Leishmania donovani ergosterol + NADP+
-
 ?
ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH + H+
-
 Leishmania donovani BPK282A1 ergosterol + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
sterol C-24 reductase
-
 Leishmania donovani

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.019
-
 pH and temperature not specified in the publication Leishmania donovani hesperidin