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Literature summary for 1.3.1.72 extracted from

  • Lu, X.; Li, Y.; Wang, W.; Chen, S.; Liu, T.; Jia, D.; Quan, X.; Sun, D.; Chang, A.K.; Gao, B.
    3 beta-hydroxysteroid-DELTA 24 reductase (DHCR24) protects neuronal cells from apoptotic cell death induced by endoplasmic reticulum (ER) stress (2014), PLoS ONE, 9, e86753 .
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information neuroblastoma N2A cells are infected with adenovirus expressing myc-tagged DHCR24 (Ad-DHCR24) or lacZ (Ad-lacZ, serving as a control) and subjected to endoplasmic reticulum-stress, induced with tunicamycin. Cells infected with Ad-DHCR24-myc are resistant to TM-induced apoptosis, and show weaker level of caspase-12 activity. The cells also exhibit lower levels of Bip and CHOP proteins than Ad-LacZ-infected cells. A stronger and rapid activation of PERK, and a prolonged activation of JNK and p38 are observed in Ad-LacZ┬ľinfected cells. The generation of intracellular reactive oxygen species from endoplasmic reticulum stress is also diminished by the overexpression of DHCR24 and intracellular cholesterol level is elevated, accompanied by a well-organized formation of caveolae (cholesterol-rich microdomain) on the plasma membrane, and improved colocalization of caveolin-1 and insulin-like growth factor 1 receptor. DHCR24 can protect neuronal cells from apoptosis induced by endoplasmic reticulum stress Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
Homo sapiens 5783
-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q15392
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Homo sapiens
-
additional information not in glial cells Homo sapiens
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neuron
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
3 beta-hydroxysteroid-DELTA 24 reductase
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Homo sapiens
DHCR24
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Homo sapiens

General Information

General Information Comment Organism
physiological function 3beta-hydroxysteroid-DELTA24 reductase (DHCR24) is an endoplasmic reticulum-localized multifunctional enzyme that possesses anti-apoptotic and cholesterol-synthesizing activities. Overexpression of DHCR24 protects neuronal cells from tunicamycin-induced apoptosis. DHCR24 may function as a neuroprotective protein under endoplasmic reticulum stress. Overexpression of DHCR24 inhibits apoptotic cell signaling and reduces or delays activation of endoplasnic reticlum stress-related cell signaling during unfolded protein response in mouse embryonic fibroblast N2A cells, overview. Elevated cholesterol levels may contribute to the neuroprotective function of DHCR24 Homo sapiens