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Literature summary for extracted from

  • Mirza, R.; Qiao, S.; Tateyama, K.; Miyamoto, T.; Xiuli, L.; Seo, H.
    3beta-Hydroxysterol-Delta24 reductase plays an important role in long bone growth by protecting chondrocytes from reactive oxygen species (2012), J. Bone Miner. Metab., 30, 144-153.
    View publication on PubMed


Cloned (Comment) Organism
overexpressed in ATDC-5 cells Mus musculus


Organism UniProt Comment Textmining
Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
ATDC-5 cell
Mus musculus


Synonyms Comment Organism
3beta-hydroxysterol-delta24 reductase
Mus musculus

General Information

General Information Comment Organism
malfunction DHCR24 knockout mice die within a few hours after birth. Cultured metatarsal bones from newborn knockout mice show a significant retarded growth. Absence of proliferating chondrocytes in the growth plate and abnormal hypertrophy of prehypertrophic chondrocytes are observed in the bones from knockout mice Mus musculus
malfunction insulin-induced reactive oxygen species production is enhanced by siRNA for DHCR24 Mus musculus
malfunction overexpression of DHCR24 protects ATDC5 cells from H2O2-induces hypertrophy. Insulin-induced hypertrophic differentiation of ATDC5 cells is associated with production of reactive oxygen species and pretreatment of the cells with siRNA for DHCR24 mRNA accelerates the hypertrophic differentiation Mus musculus