Literature summary for 1.3.1.72 extracted from

Mirza, R.; Qiao, S.; Tateyama, K.; Miyamoto, T.; Xiuli, L.; Seo, H.
3beta-Hydroxysterol-Delta24 reductase plays an important role in long bone growth by protecting chondrocytes from reactive oxygen species (2012), J. Bone Miner. Metab., 30, 144-153.

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Cloned(Commentary)

Cloned (Comment)	Organism
overexpressed in ATDC-5 cells	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
ATDC-5 cell	-	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
3beta-hydroxysterol-delta24 reductase	-	Mus musculus

General Information

General Information	Comment	Organism
malfunction	DHCR24 knockout mice die within a few hours after birth. Cultured metatarsal bones from newborn knockout mice show a significant retarded growth. Absence of proliferating chondrocytes in the growth plate and abnormal hypertrophy of prehypertrophic chondrocytes are observed in the bones from knockout mice	Mus musculus
malfunction	insulin-induced reactive oxygen species production is enhanced by siRNA for DHCR24	Mus musculus
malfunction	overexpression of DHCR24 protects ATDC5 cells from H2O2-induces hypertrophy. Insulin-induced hypertrophic differentiation of ATDC5 cells is associated with production of reactive oxygen species and pretreatment of the cells with siRNA for DHCR24 mRNA accelerates the hypertrophic differentiation	Mus musculus

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Release 2023.1 (January 2023)