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Literature summary for 1.3.1.72 extracted from

  • Kuehnle, K.; Crameri, A.; Kaelin, R.E.; Luciani, P.; Benvenuti, S.; Peri, A.; Ratti, F.; Rodolfo, M.; Kulic, L.; Heppner, F.L.; Nitsch, R.M.; Mohajeri, M.H.
    Prosurvival effect of DHCR24/seladin-1 in acute and chronic responses to oxidative stress (2008), Mol. Cell. Biol., 28, 539-550.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.3.1.72

Activating Compound

Activating Compound Comment Organism Structure
cholesterol high levels of DHCR24 are associated with elevated cholesterol concentrations Homo sapiens
H2O2 DHCR24 mRNA levels increase in response to oxidative stress (0.1 mM H2O2) in a time-dependent manner, reaching the maximum after 4 h Homo sapiens

Protein Variants

Protein Variants Comment Organism
N294T/K306N mutant shows diminished activity Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
60000
-
 SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Oxidation Stability

Oxidation Stability Organism
seladin-1 expression is up-regulated in an acute response and down-regulated in a chronic response to oxidative stress Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
SH-SY5Y cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
desmosterol + NADPH
-
 Homo sapiens cholesterol + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
3beta-hydroxysterol-delta24 reductase
-
 Homo sapiens
DHCR24
-
 Homo sapiens
seladin-1
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Homo sapiens