Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5,22-cholestedien-3beta-ol | desmosterol isomer, competitive inhibition | Homo sapiens | |
5,22-cholestedien-3beta-ol | desmosterol isomer, competitive inhibition | Rattus norvegicus | |
brassicasterol | DELTA22-unsaturated phytosterol, competitive inhibition | Homo sapiens | |
brassicasterol | DELTA22-unsaturated phytosterol, competitive inhibition | Rattus norvegicus | |
ergosterol | DELTA22-unsaturated phytosterol, competitive inhibition | Homo sapiens | |
ergosterol | DELTA22-unsaturated phytosterol, competitive inhibition | Rattus norvegicus | |
additional information | inhibition mechanism of DELTA22-unsaturated phytosterols | Homo sapiens | |
additional information | inhibition mechanism of DELTA22-unsaturated phytosterols | Rattus norvegicus | |
stigmasterol | DELTA22-unsaturated phytosterol, competitive inhibition | Homo sapiens | |
stigmasterol | DELTA22-unsaturated phytosterol, competitive inhibition | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
26.3 | - |
desmosterol | pH 7.6, 37°C | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | bound | Homo sapiens | 16020 | - |
membrane | bound | Rattus norvegicus | 16020 | - |
microsome | - |
Rattus norvegicus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5alpha-cholesta-7,24-dien-3beta-ol + NADPH | Homo sapiens | step in the biosynthesis of cholesterol from lanosterol | 5alpha-cholest-7-en-3beta-ol + NADP+ | - |
? | |
5alpha-cholesta-7,24-dien-3beta-ol + NADPH | Rattus norvegicus | step in the biosynthesis of cholesterol from lanosterol | 5alpha-cholest-7-en-3beta-ol + NADP+ | - |
? | |
cholesta-5,7,24-trien-3beta-ol + NADPH | Homo sapiens | step in the biosynthesis of cholesterol from lanosterol | cholest-5,7-dien-3beta-ol + NADP+ | - |
? | |
cholesta-5,7,24-trien-3beta-ol + NADPH | Rattus norvegicus | step in the biosynthesis of cholesterol from lanosterol | cholest-5,7-dien-3beta-ol + NADP+ | - |
? | |
desmosterol + NADPH | Homo sapiens | step in the biosynthesis of cholesterol from lanosterol | cholesterol + NADP+ | - |
? | |
desmosterol + NADPH | Rattus norvegicus | step in the biosynthesis of cholesterol from lanosterol | cholesterol + NADP+ | - |
? | |
lanosterol + NADPH | Homo sapiens | step in the biosynthesis of cholesterol from lanosterol | 24-dihydrolanosterol + NADP+ | - |
? | |
lanosterol + NADPH | Rattus norvegicus | step in the biosynthesis of cholesterol from lanosterol | 24-dihydrolanosterol + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Caco-2 cell | intestinal mucosa cells | Homo sapiens | - |
HL-60 cell | promyelocytic cells | Homo sapiens | - |
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5alpha-cholesta-7,24-dien-3beta-ol + NADPH | best substrate | Homo sapiens | 5alpha-cholest-7-en-3beta-ol + NADP+ | i.e.lathosterol | ? | |
5alpha-cholesta-7,24-dien-3beta-ol + NADPH | best substrate | Rattus norvegicus | 5alpha-cholest-7-en-3beta-ol + NADP+ | i.e.lathosterol | ? | |
5alpha-cholesta-7,24-dien-3beta-ol + NADPH | step in the biosynthesis of cholesterol from lanosterol | Homo sapiens | 5alpha-cholest-7-en-3beta-ol + NADP+ | - |
? | |
5alpha-cholesta-7,24-dien-3beta-ol + NADPH | step in the biosynthesis of cholesterol from lanosterol | Rattus norvegicus | 5alpha-cholest-7-en-3beta-ol + NADP+ | - |
? | |
cholesta-5,7,24-trien-3beta-ol + NADPH | - |
Homo sapiens | cholest-5,7-dien-3beta-ol + NADP+ | - |
? | |
cholesta-5,7,24-trien-3beta-ol + NADPH | - |
Rattus norvegicus | cholest-5,7-dien-3beta-ol + NADP+ | - |
? | |
cholesta-5,7,24-trien-3beta-ol + NADPH | step in the biosynthesis of cholesterol from lanosterol | Homo sapiens | cholest-5,7-dien-3beta-ol + NADP+ | - |
? | |
cholesta-5,7,24-trien-3beta-ol + NADPH | step in the biosynthesis of cholesterol from lanosterol | Rattus norvegicus | cholest-5,7-dien-3beta-ol + NADP+ | - |
? | |
desmosterol + NADPH | - |
Homo sapiens | cholesterol + NADP+ | - |
? | |
desmosterol + NADPH | - |
Rattus norvegicus | cholesterol + NADP+ | - |
? | |
desmosterol + NADPH | step in the biosynthesis of cholesterol from lanosterol | Homo sapiens | cholesterol + NADP+ | - |
? | |
desmosterol + NADPH | step in the biosynthesis of cholesterol from lanosterol | Rattus norvegicus | cholesterol + NADP+ | - |
? | |
lanosterol + NADPH | - |
Homo sapiens | 24-dihydrolanosterol + NADP+ | - |
? | |
lanosterol + NADPH | - |
Rattus norvegicus | 24-dihydrolanosterol + NADP+ | - |
? | |
lanosterol + NADPH | step in the biosynthesis of cholesterol from lanosterol | Homo sapiens | 24-dihydrolanosterol + NADP+ | - |
? | |
lanosterol + NADPH | step in the biosynthesis of cholesterol from lanosterol | Rattus norvegicus | 24-dihydrolanosterol + NADP+ | - |
? | |
zymosterol + NADPH | - |
Homo sapiens | 5alpha-cholesta-8-en-3beta-ol + NADP+ | - |
? | |
zymosterol + NADPH | - |
Rattus norvegicus | 5alpha-cholesta-8-en-3beta-ol + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
desmosterol reductase | - |
Homo sapiens |
desmosterol reductase | - |
Rattus norvegicus |
lanosterol reductase | - |
Homo sapiens |
lanosterol reductase | - |
Rattus norvegicus |
sterol 24DELTA-reductase | - |
Homo sapiens |
sterol 24DELTA-reductase | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.6 | - |
assay at | Homo sapiens |
7.6 | - |
assay at | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens | |
NADPH | - |
Rattus norvegicus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0033 | - |
5,22-cholestedien-3beta-ol | pH 7.6, 37°C | Rattus norvegicus | |
0.037 | - |
ergosterol | pH 7.6, 37°C | Rattus norvegicus | |
0.041 | - |
stigmasterol | pH 7.6, 37°C | Rattus norvegicus | |
0.043 | - |
brassicasterol | pH 7.6, 37°C | Rattus norvegicus |