Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-beta-(2-(diethylamino)ethoxy)androst-5-en-17-one | - |
Homo sapiens | |
3-beta-(2-(diethylamino)ethoxy)androst-5-en-17-one | - |
Rattus norvegicus | |
Calmodulin antagonists | calmodulin antagonists inhibit reduction of DELTA24 double bond; specific, dose-dependent inhibition | Homo sapiens | |
Calmodulin antagonists | calmodulin antagonists inhibit reduction of DELTA24 double bond; specific, dose-dependent inhibition | Rattus norvegicus | |
N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide | W-7, specific, dose-dependent inhibition | Homo sapiens | |
N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide | 70% inhibition; W-7, specific, dose-dependent inhibition | Rattus norvegicus | |
Trifluoperazine | specific, dose-dependent inhibition | Homo sapiens | |
Trifluoperazine | 73% inhibition; specific, dose-dependent inhibition | Rattus norvegicus | |
Triparanol | 1-[p-(beta-diethylaminoethoxy)-phenyl]-1-(p-tolyl)-2-(p-chlorophenyl)-ethanol, MER 29 | Homo sapiens | |
Triparanol | 1-[p-(beta-diethylaminoethoxy)-phenyl]-1-(p-tolyl)-2-(p-chlorophenyl)-ethanol, MER 29 | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
microsome | microsome-bound | Rattus norvegicus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
desmosterol + NADPH | Homo sapiens | 5alpha-cholesta-5,24-dien-3beta-ol | cholesterol + NADP+ | - |
? | |
desmosterol + NADPH | Rattus norvegicus | 5alpha-cholesta-5,24-dien-3beta-ol | cholesterol + NADP+ | - |
? | |
additional information | Homo sapiens | reduction of DELTA24 double bond is one of the necessary reactions during cholesterol synthesis | ? | - |
? | |
additional information | Rattus norvegicus | reduction of DELTA24 double bond is one of the necessary reactions during cholesterol synthesis | ? | - |
? | |
additional information | Homo sapiens | cholesterogenic enzyme | ? | - |
? | |
additional information | Rattus norvegicus | cholesterogenic enzyme | ? | - |
? | |
additional information | Homo sapiens | important enzyme in the 19-step pathway of cholesterol biosynthesis from lanosterol | ? | - |
? | |
additional information | Rattus norvegicus | important enzyme in the 19-step pathway of cholesterol biosynthesis from lanosterol | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
human | - |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | fibroblast from skin | Homo sapiens | - |
Hep-G2 cell | - |
Homo sapiens | - |
Hep-G2 cell | hepatoma cell line HepG2 | Homo sapiens | - |
liver | - |
Rattus norvegicus | - |
skin fibroblast | human skin fibroblast | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
desmosterol + NADPH | 5alpha-cholesta-5,24-dien-3beta-ol | Homo sapiens | cholesterol + NADP+ | - |
? | |
desmosterol + NADPH | 5alpha-cholesta-5,24-dien-3beta-ol | Rattus norvegicus | cholesterol + NADP+ | - |
? | |
lanosterol + NADPH | 4,4',14alpha-trimethyl-5alpha-cholesta-8,24-dien-3beta-ol | Homo sapiens | 4,4,14alpha-trimethyl-5alpha-cholesta-8-en-3beta-ol + NADP+ | - |
? | |
lanosterol + NADPH | 4,4',14alpha-trimethyl-5alpha-cholesta-8,24-dien-3beta-ol | Rattus norvegicus | 4,4,14alpha-trimethyl-5alpha-cholesta-8-en-3beta-ol + NADP+ | - |
? | |
additional information | catalyzes reduction of DELTA24 double bond | Homo sapiens | ? | - |
? | |
additional information | catalyzes reduction of DELTA24 double bond | Rattus norvegicus | ? | - |
? | |
additional information | reduction of DELTA24 double bond is one of the necessary reactions during cholesterol synthesis | Homo sapiens | ? | - |
? | |
additional information | reduction of DELTA24 double bond is one of the necessary reactions during cholesterol synthesis | Rattus norvegicus | ? | - |
? | |
additional information | cholesterogenic enzyme | Homo sapiens | ? | - |
? | |
additional information | cholesterogenic enzyme | Rattus norvegicus | ? | - |
? | |
additional information | important enzyme in the 19-step pathway of cholesterol biosynthesis from lanosterol | Homo sapiens | ? | - |
? | |
additional information | important enzyme in the 19-step pathway of cholesterol biosynthesis from lanosterol | Rattus norvegicus | ? | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
37 | - |
assay at | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens | |
NADPH | - |
Rattus norvegicus |