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Literature summary for 1.3.1.71 extracted from

  • Visbal, G.; Alvarez, A.; Moreno, B.; San-Blas, G.
    S-adenosyl-L-methionine inhibitors DELTA24-sterol methyltransferase and DELTA24(28)-sterol methylreductase as possible agents against Paracoccidioides brasiliensis (2003), Antimicrob. Agents Chemother., 47, 2966-2970.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
20-piperidin-2-yl-5alpha-pregnan-20(R),3beta-diol i.e. AZA-1, inhibits the enzyme and the DELTA24-sterol methyltransferase, leads to accumulation of ergosta-5,7,24(28)-trien-3beta-ol in vivo Paracoccidioides brasiliensis
22-piperidin-2-yl-5alpha-pregnan-3beta,22(S)-diol i.e. AZA-2, specific inhibition of the enzyme, leads to accumulatin of ergosta-5,7,22,24(28)-tetraen-3beta-ol in vivo Paracoccidioides brasiliensis
22-piperidin-3-yl-5alpha-pregnan-3beta,22(S)-diol i.e. AZA-3, inhibits the enzyme, major proliferative effect and accumulation of lanosterol in vivo Paracoccidioides brasiliensis
additional information sterol composition with or without addition of azasterol analogue inhibitors, overview Paracoccidioides brasiliensis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH Paracoccidioides brasiliensis step in the biosynthesis of ergosta-5,22-dien-3bta-ol, i.e. brassicasterol, the major sterol compound in Paracoccidioides brasiliensis ergosterol + NADP+
-
 ?
additional information Paracoccidioides brasiliensis sterol composition with or without addition of azasterol analogue inhibitors, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Paracoccidioides brasiliensis
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 dimorphic fungus
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Source Tissue

Source Tissue Comment Organism Textmining
additional information organism in its pathogenic yeast-like phase Paracoccidioides brasiliensis
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH
-
 Paracoccidioides brasiliensis ergosterol + NADP+
-
 ?
ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH step in the biosynthesis of ergosta-5,22-dien-3bta-ol, i.e. brassicasterol, the major sterol compound in Paracoccidioides brasiliensis Paracoccidioides brasiliensis ergosterol + NADP+
-
 ?
additional information sterol composition with or without addition of azasterol analogue inhibitors, overview Paracoccidioides brasiliensis ?
-
 ?

Synonyms

Synonyms Comment Organism
DELTA24(28)-sterol methylreductase
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 Paracoccidioides brasiliensis
SMR
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 Paracoccidioides brasiliensis

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Paracoccidioides brasiliensis