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Literature summary for 1.3.1.70 extracted from

  • Li, Y.; Dai, M.; Zhang, Y.; Lu, L.
    The sterol C-14 reductase Erg24 is responsible for ergosterol biosynthesis and ion homeostasis in Aspergillus fumigatus (2021), Appl. Microbiol. Biotechnol., 105, 1253-1268 .
    View publication on PubMed
Search for more literature for 1.3.1.70

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
 Aspergillus fumigatus 5783
-

Organism

Organism UniProt Comment Textmining
Aspergillus fumigatus B0XMW7
-
-
Aspergillus fumigatus B0XP65
-
-
Aspergillus fumigatus FGSC A1163 B0XMW7
-
-
Aspergillus fumigatus FGSC A1163 B0XP65
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4,4-dimethyl-5alpha-cholesta-8,12,24-trien-3beta-ol + NADPH + H+
-
 Aspergillus fumigatus 4,4-dimethylzymosterol + NADP+
-
 ?
4,4-dimethyl-5alpha-cholesta-8,12,24-trien-3beta-ol + NADPH + H+
-
 Aspergillus fumigatus FGSC A1163 4,4-dimethylzymosterol + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
ERG24
-
 Aspergillus fumigatus
erg24A
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 Aspergillus fumigatus
erg24B
-
 Aspergillus fumigatus
sterol C-14 reductase
-
 Aspergillus fumigatus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Aspergillus fumigatus

General Information

General Information Comment Organism
malfunction inactivation of both homologs of Erg24 results in decreased hyphal growth and virulence, leads to the disruption of ion homeostasis and affects ergosterol biosynthesis. Loss of one homolog of Erg24 impairs hyphal growth, conidiation, and virulence but has no effect on ergosterol biosynthesis Aspergillus fumigatus
physiological function both erg24A and erg24B homologs in combination, but not individuall, are essential for the viability of Aspergillus fumigatus. The enzyme plays a critical role in ergosterol biosynthesis and ion homeostasis Aspergillus fumigatus
physiological function erg24A and erg24B homologs in combination, but not individually, are essential for the viability of Aspergillus fumigatus. The enzyme plays a critical role in ergosterol biosynthesis and ion homeostasis Aspergillus fumigatus