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Literature summary for 1.3.1.70 extracted from
- Cloning, sequencing, and disruption of the gene encoding sterol C-14 reductase in Saccharomyces cerevisiae (1992), DNA Cell Biol., 11, 685-692.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| wild-type ERG24 gene, wild-type C-14 reductase | Saccharomyces cerevisiae |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 15-azasterol | - |
Saccharomyces cerevisiae |  |
| fenpropimorph | - |
Saccharomyces cerevisiae | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 50610 | - |
amino acid analysis | Saccharomyces cerevisiae |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH | Saccharomyces cerevisiae | - |
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+ | - |
? | |
| additional information | Saccharomyces cerevisiae | essential enzyme of ergosterol, yeast sterol, biosynthesis from lanosterol | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH | - |
Saccharomyces cerevisiae | 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+ | - |
? | |
| ergosta-8,14-dien-3beta-ol + NADPH | DELTA8,14-sterol, ignosterol | Saccharomyces cerevisiae | ergosta-8-en-3beta-ol + NADP+ | - |
? | |
| additional information | essential enzyme of ergosterol, yeast sterol, biosynthesis from lanosterol | Saccharomyces cerevisiae | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ERG 24 | ERG24 represents C-14 reductase | Saccharomyces cerevisiae |
| ERG24 | ERG24 represents C-14 reductase | Saccharomyces cerevisiae |
| erg24-1 | - |
Saccharomyces cerevisiae |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Saccharomyces cerevisiae | |
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Release 2023.1 (January 2023)
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