Organism | UniProt | Comment | Textmining |
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Caenorhabditis elegans | - |
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General Information | Comment | Organism |
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physiological function | the increased longevity of worms provided by malate addition does not occur in fumarase fum-1, glyoxylate shunt gei-7, succinate dehydrogenase flavoprotein sdha-2, or soluble fumarate reductase F48E8.3 RNAi knockdown worms. Therefore, to increase lifespan, malate must be first converted to fumarate, then fumarate must be reduced to succinate by soluble fumarate reductase and the mitochondrial electron transport chain complex II. Fumarate reduction, glyoxylate shunt activity, and mild mitochondrial uncoupling likely contribute to the lifespan extension induced by malate and fumarate by increasing the amount of oxidized NAD and FAD cofactors | Caenorhabditis elegans |