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Literature summary for 1.3.1.34 extracted from

  • Semini, G.; Paape, D.; Blume, M.; Sernee, M.F.; Peres-Alonso, D.; Calvignac-Spencer, S.; Doellinger, J.; Jehle, S.; Saunders, E.; McConville, M.J.; Aebischer, T.
    Leishmania encodes a bacterium-like 2,4-dienoyl-coenzyme A reductase that is required for fatty acid beta-oxidation and intracellular parasite survival (2020), mBio, 11, e01057 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.3.1.34

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Leishmania major 5739
-

Organism

Organism UniProt Comment Textmining
Leishmania major
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
amastigote
-
 Leishmania major
-
promastigote
-
 Leishmania major
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(2E,4E)-2,4-decadienoyl-CoA + NADPH + H+
-
 Leishmania major (2E)-2-decaenoyl-CoA + NADP+
-
 ?

Expression

Organism Comment Expression
Leishmania major expression of DECR is highly upregulated in amastigote stages up

General Information

General Information Comment Organism
physiological function DECR is the major reductase involved in polyunsaturated fatty acid beta-oxidation. DECR is related to bacterial reductases. A DECR null mutant is unable to catabolize unsaturated fatty acids and accumulates the intermediate 2,4-decadienoyl-CoA. The mutant is unable to survive in macrophages and is avirulent in BALB/c mice Leishmania major