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Literature summary for 1.3.1.24 extracted from

  • Barone, E.; Tramutola, A.; Triani, F.; Calcagnini, S.; Di Domenico, F.; Ripoli, C.; Gaetani, S.; Grassi, C.; Butterfield, D.A.; Cassano, T.; Perluigi, M.
    Biliverdin reductase-A mediates the beneficial effects of intranasal insulin in Alzheimer Disease (2019), Mol. Neurobiol., 56, 2922-2943 .
    View publication on PubMed
Search for more literature for 1.3.1.24

Organism

Organism UniProt Comment Textmining
Mus musculus Q9CY64
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-

Source Tissue

Source Tissue Comment Organism Textmining
brain
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 Mus musculus
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Synonyms

Synonyms Comment Organism
Biliverdin reductase-A
-
 Mus musculus
BVR-A
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 Mus musculus

General Information

General Information Comment Organism
drug target the enzyme (BVR-A) is a potential therapeutic target to prevent brain insulin resistance in Alzheimer disease Mus musculus
malfunction impairment of biliverdin reductase-A (BVR-A) is an early event leading to brain insulin resistance in Alzheimer disease. Cells lacking the enzyme (BVR-A) develop insulin resistance if treated with insulin and can be recovered from insulin resistance only if treated with a BVR-A-mimetic peptide Mus musculus