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Literature summary for 1.3.1.24 extracted from

  • Franklin, E.; Mantle, T.; Dunne, A.
    Activation of human biliverdin-IXalpha reductase by urea: generation of kinetically distinct forms during the unfolding pathway (2013), Biochim. Biophys. Acta, 1834, 2573-2578.
    View publication on PubMed
Search for more literature for 1.3.1.24

Activating Compound

Activating Compound Comment Organism Structure
Urea the enzyme is activated at low concentrations of urea Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Biliverdin
-
 Homo sapiens
NAD+
-
 Homo sapiens
NADP+
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.001
-
 NADPH in the absence of urea, at pH 7.2 and 25°C Homo sapiens
0.003
-
 NADPH in the presence of 3 M urea, at pH 7.2 and 25°C Homo sapiens
0.33
-
 NADH in the absence of urea, at pH 7.2 and 25°C Homo sapiens
2
-
 NADH in the presence of 3 M urea, at pH 7.2 and 25°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
biliverdin + NADH + H+ Homo sapiens
-
 bilirubin + NAD+
-
 r
biliverdin + NADPH + H+ Homo sapiens
-
 bilirubin + NADP+
-
 r

Organism

Organism UniProt Comment Textmining
Homo sapiens P53004
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
biliverdin + NADH + H+
-
 Homo sapiens bilirubin + NAD+
-
 r
biliverdin + NADPH + H+
-
 Homo sapiens bilirubin + NADP+
-
 r

Synonyms

Synonyms Comment Organism
biliverdin-IXalpha reductase
-
 Homo sapiens
BVR-A
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADH
-
 Homo sapiens
NADPH
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00035
-
 NADP+ in the presence of 3 M urea, at pH 7.2 and 25°C Homo sapiens
0.0016
-
 NADP+ in the absence of urea, at pH 7.2 and 25°C Homo sapiens
0.028
-
 Biliverdin in the absence of urea, at pH 7.2 and 25°C Homo sapiens
0.147
-
 Biliverdin in the presence of 3 M urea, at pH 7.2 and 25°C Homo sapiens
0.3
-
 NAD+ in the absence of urea, at pH 7.2 and 25°C Homo sapiens
1.7
-
 NAD+ in the presence of 3 M urea, at pH 7.2 and 25°C Homo sapiens