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Literature summary for 1.3.1.24 extracted from

  • Gibbs, P.E.; Miralem, T.; Maines, M.D.
    Characterization of the human biliverdin reductase gene structure and regulatory elements: promoter activity is enhanced by hypoxia and suppressed by TNF-alpha-activated NF-kappaB (2010), FASEB J., 24, 3239-3254.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm in normoxic cells, hBVR is located primarily in the cytoplasm, with some protein also being seen in the nucleus Homo sapiens 5737
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nucleus hBVR is detected in the nucleus at 1, 2, and 4 h after hypoxia, at which times its kinase and reductase activities are increased Homo sapiens 5634
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Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
hypoxia activates hBVR activity Homo sapiens

Synonyms

Synonyms Comment Organism
biliverdin reductase
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens hypoxia positively regulates hBVR promoter up
Homo sapiens overexpression of IkappaB increases hBVR mRNA up
Homo sapiens TNF-alpha negatively regulates hBVR promoter up